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    Trpv2 transient receptor potential cation channel, subfamily V, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 22368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trpv2provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily V, member 2provided by MGI
    Primary source
    MGI:MGI:1341836
    See related
    Ensembl:ENSMUSG00000018507 AllianceGenome:MGI:1341836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GRC; Vrl1; VRL-1; OTRPC2
    Summary
    Enables calcium channel activity. Involved in positive regulation of axon extension; positive regulation of calcium ion import; and positive regulation of cold-induced thermogenesis. Located in cell body; cell surface; and growth cone. Is expressed in central nervous system; dorsal root ganglion; sensory organ; and testis. Orthologous to human TRPV2 (transient receptor potential cation channel subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 24.2), placenta adult (RPKM 13.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trpv2 in Genome Data Viewer
    Location:
    11 B2; 11 38.48 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62465312..62491131)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62574486..62600305)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12279 Neighboring gene STARR-seq mESC enhancer starr_29713 Neighboring gene ubiquitin B Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:62387853-62388036 Neighboring gene RIKEN cDNA 2410006H16 gene Neighboring gene STARR-positive B cell enhancer ABC_E9364 Neighboring gene small nucleolar RNA, C/D box 49B Neighboring gene small nucleolar RNA, C/D box 49A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RANKL-induced TRPV2 expression regulates osteoclastogenesis via calcium oscillations. Kajiya H, et al. Cell Calcium, 2010 Nov. PMID 20980052
    2. Transient receptor potential vanilloid 2 function regulates cardiac hypertrophy via stretch-induced activation. Koch SE, et al. J Hypertens, 2017 Mar. PMID 28009703
    3. Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes. Sun W, et al. Pflugers Arch, 2016 Sep. PMID 27318696
    4. TRPV2 knockout mice demonstrate an improved cardiac performance following myocardial infarction due to attenuated activity of peri-infarct macrophages. Entin-Meer M, et al. PLoS One, 2017. PMID 28481959, Free PMC Article
    5. TRPV2 ion channels expressed in inhibitory motor neurons of gastric myenteric plexus contribute to gastric adaptive relaxation and gastric emptying in mice. Mihara H, et al. Am J Physiol Gastrointest Liver Physiol, 2013 Feb 1. PMID 23203157

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tyrosine phosphorylation and palmitoylation of TRPV2 ion channel tune microglial beta-amyloid peptide phagocytosis.
      Title: Tyrosine phosphorylation and palmitoylation of TRPV2 ion channel tune microglial beta-amyloid peptide phagocytosis.
    2. Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21.
      Title: Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21.
    3. Ion channel TRPV2 is critical in enhancing B cell activation and function.
      Title: Ion channel TRPV2 is critical in enhancing B cell activation and function.
    4. High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling.
      Title: High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling.
    5. Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta.
      Title: Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta.
    6. Knockdown of TRPV2 inhibits the migration of RAW264.7 cells toward low fluid shear stress region.
      Title: Knockdown of TRPV2 inhibits the migration of RAW264.7 cells toward low fluid shear stress region.
    7. The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca[2+] -LRMDA Axis in Myeloid Cells.
      Title: The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca(2+) -LRMDA Axis in Myeloid Cells.
    8. Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus.
      Title: Genetic mutation of TRPV2 induces anxiety by decreasing GABA-B R2 expression in hippocampus.
    9. Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.
      Title: Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.
    10. Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription.
      Title: Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription.
    Submit: New GeneRIF Correction See all GeneRIFs (58)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to temperature stimulus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transient receptor potential cation channel subfamily V member 2
    Names
    growth factor regulated channel
    growth factor-regulated calcium channel
    osm-9-like TRP channel 2
    vanilloid receptor-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382489.1 → NP_001369418.1  transient receptor potential cation channel subfamily V member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596181
      UniProtKB/Swiss-Prot
      Q99K71, Q9WTR1
      Conserved Domains (2) summary
      sd00045
      Location:158 → 189
      ANK; ANK repeat [structural motif]
      cd22197
      Location:66 → 705
      TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

    2. NM_001382490.1 → NP_001369419.1  transient receptor potential cation channel subfamily V member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596181
      UniProtKB/Swiss-Prot
      Q99K71, Q9WTR1
      Conserved Domains (2) summary
      sd00045
      Location:158 → 189
      ANK; ANK repeat [structural motif]
      cd22197
      Location:66 → 705
      TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

    3. NM_001382491.1 → NP_001369420.1  transient receptor potential cation channel subfamily V member 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL596181
      Conserved Domains (2) summary
      sd00045
      Location:158 → 189
      ANK; ANK repeat [structural motif]
      cl40437
      Location:66 → 658
      TRPV; Transient Receptor Potential channel, Vanilloid subfamily (TRPV)

    4. NM_001382492.1 → NP_001369421.1  transient receptor potential cation channel subfamily V member 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL596181
      Conserved Domains (2) summary
      sd00045
      Location:158 → 189
      ANK; ANK repeat [structural motif]
      cl40437
      Location:66 → 647
      TRPV; Transient Receptor Potential channel, Vanilloid subfamily (TRPV)

    5. NM_011706.2 → NP_035836.2  transient receptor potential cation channel subfamily V member 2 isoform 1

      See identical proteins and their annotated locations for NP_035836.2

      Status: VALIDATED

      Source sequence(s)
      AK008689, BB631765, BY648241
      Consensus CDS
      CCDS24827.1
      UniProtKB/Swiss-Prot
      Q99K71, Q9WTR1
      Related
      ENSMUSP00000018651.8, ENSMUST00000018651.14
      Conserved Domains (2) summary
      sd00045
      Location:158 → 189
      ANK; ANK repeat [structural motif]
      cd22197
      Location:66 → 705
      TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62465312..62491131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156630.1 → XP_036012523.1  transient receptor potential cation channel subfamily V member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q99K71, Q9WTR1
      Related
      ENSMUSP00000099703.2, ENSMUST00000102643.2
      Conserved Domains (2) summary
      sd00045
      Location:158 → 189
      ANK; ANK repeat [structural motif]
      cd22197
      Location:66 → 705
      TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTR1.2 GenPept UniProtKB/Swiss-Prot:Q9WTR1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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