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    Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit [ Mus musculus (house mouse) ]

    Gene ID: 12290, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cacna1eprovided by MGI
    Official Full Name
    calcium channel, voltage-dependent, R type, alpha 1E subunitprovided by MGI
    Primary source
    MGI:MGI:106217
    See related
    Ensembl:ENSMUSG00000004110 AllianceGenome:MGI:106217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BII; Cach6; Cav2.3; Cchra1; alpha1E; Cacnl1a6; A430040I15
    Summary
    This gene encodes an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes. Voltage-dependent calcium channels are multi-subunit complexes, comprised of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The isoform alpha-1E gives rise to R-type calcium currents and belongs to the high-voltage activated group. Calcium channels containing the alpha-1E subunit may be involved in the modulation of neuronal firing patterns, an important component of information processing. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in frontal lobe adult (RPKM 6.4), cortex adult (RPKM 6.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cacna1e in Genome Data Viewer
    Location:
    1 G3; 1 66.14 cM
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (154266552..154760374, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (154390806..154884785, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930532M18 gene Neighboring gene predicted gene, 30465 Neighboring gene golgi SNAP receptor complex member 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:156464654-156464955 Neighboring gene STARR-positive B cell enhancer mm9_chr1:156493503-156493803 Neighboring gene STARR-seq mESC enhancer starr_02714 Neighboring gene STARR-seq mESC enhancer starr_02715 Neighboring gene STARR-seq mESC enhancer starr_02716 Neighboring gene STARR-positive B cell enhancer ABC_E4359 Neighboring gene STARR-positive B cell enhancer ABC_E2014 Neighboring gene predicted gene, 51649 Neighboring gene STARR-seq mESC enhancer starr_02717 Neighboring gene STARR-positive B cell enhancer mm9_chr1:156696300-156696601 Neighboring gene STARR-positive B cell enhancer mm9_chr1:156698156-156698457 Neighboring gene STARR-seq mESC enhancer starr_02718 Neighboring gene predicted gene, 30521 Neighboring gene predicted gene, 41976 Neighboring gene predicted gene, 30602

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CaV2.3 R-type voltage-gated Ca2+ channel in mouse sleep architecture. Siwek ME, et al. Sleep, 2014 May 1. PMID 24790266, Free PMC Article
    2. Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel. Weiergräber M, et al. Epilepsia, 2006 May. PMID 16686648
    3. Modulation of Ca(v)2.3 channels by unconjugated bilirubin (UCB) - Candidate mechanism for UCB-induced neuromodulation and neurotoxicity. Albanna W, et al. Mol Cell Neurosci, 2019 Apr. PMID 30877033
    4. The Ca(V)2.3 Ca(2+) channel subunit contributes to R-type Ca(2+) currents in murine hippocampal and neocortical neurones. Sochivko D, et al. J Physiol, 2002 Aug 1. PMID 12154172, Free PMC Article
    5. Unconjugated bilirubin modulates neuronal signaling only in wild-type mice, but not after ablation of the R-type/Ca(v) 2.3 voltage-gated calcium channel. Albanna W, et al. CNS Neurosci Ther, 2018 Mar. PMID 29274300, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability.
      Title: Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability.
    2. L-cysteine modulates visceral nociception mediated by the CaV2.3 R-type calcium channels.
      Title: L-cysteine modulates visceral nociception mediated by the Ca(V)2.3 R-type calcium channels.
    3. GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
      Title: GABA(B) receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.
    4. Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression.
      Title: Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression.
    5. Cav2.3 channels are regulators of nigral neuronal viability. Cav2.3 knockout reduced activity-associated nigral somatic Ca2+ signals and Ca2+-dependent after-hyperpolarizations, and afforded full protection from degeneration in vivo in a neurotoxin Parkinson's mouse model. Cav2.3 deficiency upregulated transcripts for NCS-1. Conversely, NCS-1 knockout exacerbated nigral neurodegeneration and downregulated Cav2.3.
      Title: Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease.
    6. The ex vivo neuronal setup of the isolated and superfused murine retina demonstrates a transient effect of bilirubin on neuronal signaling only when Cav2.3/R-type channels are present. Modulation of Cav2.3/R-type Ca2+ channels may contribute to the pathophysiological cascades of vasospasm or delayed cerebral ischemia.
      Title: Unconjugated bilirubin modulates neuronal signaling only in wild-type mice, but not after ablation of the R-type/Ca(v) 2.3 voltage-gated calcium channel.
    7. The results of this study showed that Cav2.3 is a novel mechanistic target for a key pronociceptive miRNA, miR-34c-5p.
      Title: miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels.
    8. Data show that apamin boosts evoked excitatory postsynaptic potentials (EPSPs) in CaV2.3 R-Type Ca2+ Channel knockout (CaV2.3-/-) mice.
      Title: Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice.
    9. under conditions of Zn2+ deficiency, ablation or dysfunction of Cav2.3 channels may lead to severe disturbances in glucose homeostasis.
      Title: Diethyldithiocarbamate-mediated zinc ion chelation reveals role of Cav2.3 channels in glucagon secretion.
    10. Cav2.1-2.3 have unique contributions to the dynamics at the Schaffer collateral synapse that are engaged by the complex patterns of afferent activity seen in vivo
      Title: Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within behavioral response to pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fear response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nervous system process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of somatostatin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated calcium channel complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated calcium channel complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    voltage-dependent R-type calcium channel subunit alpha-1E
    Names
    brain calcium channel II
    calcium channel, L type, alpha-1 polypeptide
    calcium channel, voltage-dependent, L type, alpha 1E subunit
    voltage-gated calcium channel subunit alpha Cav2.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009782.3 → NP_033912.2  voltage-dependent R-type calcium channel subunit alpha-1E

      Status: REVIEWED

      Source sequence(s)
      AC099707, AC101727, AC122040
      Consensus CDS
      CCDS78710.1
      UniProtKB/TrEMBL
      A0A087WS83, B2RWX7
      Related
      ENSMUSP00000140937.2, ENSMUST00000187541.7
      Conserved Domains (5) summary
      pfam00520
      Location:1498 → 1737
      Ion_trans; Ion transport protein
      pfam05439
      Location:341 → 374
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:2013 → 2117
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:1810 → 1884
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1745 → 1808
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      154266552..154760374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243929.1 → XP_030099789.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1626 → 1883
      Ion_trans; Ion transport protein
      pfam08763
      Location:1956 → 2029
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2168 → 2243
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1892 → 1945
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    2. XM_017312578.3 → XP_017168067.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1626 → 1883
      Ion_trans; Ion transport protein
      pfam08763
      Location:1956 → 2029
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2168 → 2243
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1892 → 1945
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    3. XM_017312848.1 → XP_017168337.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X14

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1480 → 1737
      Ion_trans; Ion transport protein
      pfam08763
      Location:1810 → 1883
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2022 → 2097
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1746 → 1799
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    4. XM_017312712.1 → XP_017168201.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X8

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1596 → 1853
      Ion_trans; Ion transport protein
      pfam08763
      Location:1926 → 1999
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2138 → 2213
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1862 → 1915
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    5. XM_017312660.1 → XP_017168149.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X6

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1607 → 1864
      Ion_trans; Ion transport protein
      pfam08763
      Location:1937 → 2010
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2149 → 2224
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1873 → 1926
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    6. XM_017312628.1 → XP_017168117.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X4

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1622 → 1879
      Ion_trans; Ion transport protein
      pfam08763
      Location:1952 → 2025
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2164 → 2239
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1888 → 1941
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    7. XM_017312642.1 → XP_017168131.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X5

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1622 → 1879
      Ion_trans; Ion transport protein
      pfam08763
      Location:1952 → 2025
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2164 → 2239
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1888 → 1941
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    8. XM_017312619.1 → XP_017168108.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X3

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1626 → 1883
      Ion_trans; Ion transport protein
      pfam08763
      Location:1956 → 2029
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2164 → 2239
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1892 → 1945
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    9. XM_017312730.1 → XP_017168219.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X9

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1626 → 1883
      Ion_trans; Ion transport protein
      pfam08763
      Location:1956 → 2029
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2125 → 2200
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1892 → 1945
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    10. XM_017312613.1 → XP_017168102.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X2

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1626 → 1883
      Ion_trans; Ion transport protein
      pfam08763
      Location:1956 → 2029
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2168 → 2243
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1892 → 1945
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    11. XM_030243926.1 → XP_030099786.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1626 → 1883
      Ion_trans; Ion transport protein
      pfam08763
      Location:1956 → 2029
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2168 → 2243
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1892 → 1945
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    12. XM_011247909.4 → XP_011246211.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

      See identical proteins and their annotated locations for XP_011246211.1

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1626 → 1883
      Ion_trans; Ion transport protein
      pfam08763
      Location:1956 → 2029
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2168 → 2243
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1892 → 1945
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    13. XM_011247916.4 → XP_011246218.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X14

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1480 → 1737
      Ion_trans; Ion transport protein
      pfam08763
      Location:1810 → 1883
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2022 → 2097
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1746 → 1799
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    14. XM_030244154.2 → XP_030100014.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X15

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam17069
      Location:1966 → 2090
      RSRP; Arginine/Serine-Rich protein 1
      pfam00520
      Location:1431 → 1688
      Ion_trans; Ion transport protein
      pfam08763
      Location:1761 → 1834
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1697 → 1750
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    15. XM_017312745.2 → XP_017168234.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X10

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1626 → 1883
      Ion_trans; Ion transport protein
      pfam08763
      Location:1956 → 2029
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2121 → 2196
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1892 → 1945
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    16. XM_017312824.2 → XP_017168313.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X13

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1607 → 1864
      Ion_trans; Ion transport protein
      pfam08763
      Location:1937 → 2010
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2102 → 2177
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1873 → 1926
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    17. XM_017312766.2 → XP_017168255.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X11

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1626 → 1883
      Ion_trans; Ion transport protein
      pfam08763
      Location:1956 → 2029
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2121 → 2196
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1892 → 1945
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    18. XM_017312795.2 → XP_017168284.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X12

      UniProtKB/TrEMBL
      B2RWX7
      Conserved Domains (4) summary
      pfam00520
      Location:1607 → 1864
      Ion_trans; Ion transport protein
      pfam08763
      Location:1937 → 2010
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2102 → 2177
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1873 → 1926
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    19. XM_017312682.2 → XP_017168171.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X7

      UniProtKB/TrEMBL
      B2RWX7
      Related
      ENSMUSP00000148507.2, ENSMUST00000211821.2
      Conserved Domains (4) summary
      pfam00520
      Location:1607 → 1864
      Ion_trans; Ion transport protein
      pfam08763
      Location:1937 → 2010
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam10500
      Location:2145 → 2220
      SR-25; Nuclear RNA-splicing-associated protein
      pfam16905
      Location:1873 → 1926
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    20. XM_036155941.1 → XP_036011834.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X16

      UniProtKB/Swiss-Prot
      Q61290
      Conserved Domains (3) summary
      pfam00520
      Location:1626 → 1883
      Ion_trans; Ion transport protein
      pfam08763
      Location:1956 → 2029
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1892 → 1945
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    21. XM_006529105.5 → XP_006529168.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X17

      Conserved Domains (1) summary
      pfam00520
      Location:1626 → 1883
      Ion_trans; Ion transport protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61290.1 GenPept UniProtKB/Swiss-Prot:Q61290

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