U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cdh12 cadherin 12 [ Mus musculus (house mouse) ]

    Gene ID: 215654, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cdh12provided by MGI
    Official Full Name
    cadherin 12provided by MGI
    Primary source
    MGI:MGI:109503
    See related
    Ensembl:ENSMUSG00000040452 AllianceGenome:MGI:109503
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdhb
    Summary
    This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is expressed in both the excitatory and inhibitory neurons in various areas of the adult central nervous system including the cerebellum, neocortex, hippocampus and in different subcortical nuclei. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in cortex adult (RPKM 1.4), frontal lobe adult (RPKM 0.9) and 5 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cdh12 in Genome Data Viewer
    Location:
    15 A2; 15 8.25 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (20448967..21598668)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (20448878..21598421)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25976 Neighboring gene STARR-seq mESC enhancer starr_38117 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_38118 Neighboring gene STARR-seq mESC enhancer starr_38119 Neighboring gene acyl-CoA thioesterase 10 Neighboring gene predicted gene, 25711 Neighboring gene STARR-seq mESC enhancer starr_38121 Neighboring gene STARR-seq mESC enhancer starr_38122 Neighboring gene STARR-seq mESC enhancer starr_38123 Neighboring gene STARR-seq mESC enhancer starr_38124 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene, 25101 Neighboring gene STARR-seq mESC enhancer starr_38125 Neighboring gene STARR-seq mESC enhancer starr_38126 Neighboring gene STARR-seq mESC enhancer starr_38127 Neighboring gene STARR-seq mESC enhancer starr_38128 Neighboring gene STARR-seq mESC enhancer starr_38129 Neighboring gene STARR-seq mESC enhancer starr_38132 Neighboring gene STARR-seq mESC enhancer starr_38133 Neighboring gene STARR-seq mESC enhancer starr_38134 Neighboring gene STARR-seq mESC enhancer starr_38135 Neighboring gene predicted gene, 41278 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene 2 Neighboring gene cadherin 18

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin. Selig S, et al. Proc Natl Acad Sci U S A, 1997 Mar 18. PMID 9122206, Free PMC Article
    2. Expression of two type II cadherins, Cdh12 and Cdh22 in the developing and adult mouse brain. Mayer M, et al. Gene Expr Patterns, 2010 Oct-Dec. PMID 20723620
    3. Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy. Lefkovics K, et al. J Comp Neurol, 2012 May 1. PMID 22102170
    4. Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse. Polanco J, et al. Front Mol Neurosci, 2021. PMID 33833667, Free PMC Article
    5. Type II cadherins guide assembly of a direction-selective retinal circuit. Duan X, et al. Cell, 2014 Aug 14. PMID 25126785

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC92959

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cadherin-12
    Names
    Br-cadherin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008420.3 → NP_001008420.1  cadherin-12 preproprotein

      See identical proteins and their annotated locations for NP_001008420.1

      Status: VALIDATED

      Source sequence(s)
      AC116657, AC118645, AC119811, AC122340
      Consensus CDS
      CCDS27396.1
      UniProtKB/Swiss-Prot
      Q5RJH3
      Related
      ENSMUSP00000074632.7, ENSMUST00000075132.8
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:638 → 785
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      20448967..21598668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245344.4 → XP_011243646.1  cadherin-12 isoform X1

      See identical proteins and their annotated locations for XP_011243646.1

      UniProtKB/Swiss-Prot
      Q5RJH3
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:638 → 785
      Cadherin_C; Cadherin cytoplasmic region

    2. XM_036159314.1 → XP_036015207.1  cadherin-12 isoform X1

      UniProtKB/Swiss-Prot
      Q5RJH3
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:638 → 785
      Cadherin_C; Cadherin cytoplasmic region

    3. XM_011245342.4 → XP_011243644.1  cadherin-12 isoform X1

      See identical proteins and their annotated locations for XP_011243644.1

      UniProtKB/Swiss-Prot
      Q5RJH3
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:638 → 785
      Cadherin_C; Cadherin cytoplasmic region

    4. XM_011245345.4 → XP_011243647.1  cadherin-12 isoform X1

      See identical proteins and their annotated locations for XP_011243647.1

      UniProtKB/Swiss-Prot
      Q5RJH3
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:638 → 785
      Cadherin_C; Cadherin cytoplasmic region

    5. XM_011245341.4 → XP_011243643.1  cadherin-12 isoform X1

      See identical proteins and their annotated locations for XP_011243643.1

      UniProtKB/Swiss-Prot
      Q5RJH3
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:638 → 785
      Cadherin_C; Cadherin cytoplasmic region

    6. XM_017316546.3 → XP_017172035.1  cadherin-12 isoform X1

      UniProtKB/Swiss-Prot
      Q5RJH3
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:638 → 785
      Cadherin_C; Cadherin cytoplasmic region

    7. XM_030248459.2 → XP_030104319.1  cadherin-12 isoform X2

      Conserved Domains (2) summary
      cd11304
      Location:102 → 209
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:467 → 614
      Cadherin_C; Cadherin cytoplasmic region

    8. XM_011245343.4 → XP_011243645.1  cadherin-12 isoform X1

      See identical proteins and their annotated locations for XP_011243645.1

      UniProtKB/Swiss-Prot
      Q5RJH3
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:638 → 785
      Cadherin_C; Cadherin cytoplasmic region

    9. XM_017316545.1 → XP_017172034.1  cadherin-12 isoform X1

      UniProtKB/Swiss-Prot
      Q5RJH3
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:638 → 785
      Cadherin_C; Cadherin cytoplasmic region

    10. XM_017316547.3 → XP_017172036.1  cadherin-12 isoform X2

      Conserved Domains (2) summary
      cd11304
      Location:102 → 209
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:467 → 614
      Cadherin_C; Cadherin cytoplasmic region

    11. XM_011245347.4 → XP_011243649.1  cadherin-12 isoform X1

      See identical proteins and their annotated locations for XP_011243649.1

      UniProtKB/Swiss-Prot
      Q5RJH3
      Related
      ENSMUSP00000153750.2, ENSMUST00000227496.2
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:638 → 785
      Cadherin_C; Cadherin cytoplasmic region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RJH3.1 GenPept UniProtKB/Swiss-Prot:Q5RJH3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous