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    Zfp428 zinc finger protein 428 [ Mus musculus (house mouse) ]

    Gene ID: 232969, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp428provided by MGI
    Official Full Name
    zinc finger protein 428provided by MGI
    Primary source
    MGI:MGI:1916463
    See related
    Ensembl:ENSMUSG00000064264 AllianceGenome:MGI:1916463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf428; 2410005H09Rik
    Summary
    Predicted to enable metal ion binding activity. Is expressed in cortical plate. Orthologous to human ZNF428 (zinc finger protein 428). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 55.2), CNS E18 (RPKM 51.2) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp428 in Genome Data Viewer
    Location:
    7 A3; 7 11.18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24203973..24215107)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24504548..24515682)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene plasminogen activator, urokinase receptor Neighboring gene cell adhesion molecule 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25315449-25315632 Neighboring gene immunity-related GTPase family, Q Neighboring gene STARR-seq mESC enhancer starr_18269 Neighboring gene phospholipase A2 inhibitor and LY6/PLAUR domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38830

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 428

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290461.1 → NP_001277390.1  zinc finger protein 428 isoform a

      See identical proteins and their annotated locations for NP_001277390.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK139174, BX527127, CX204922
      Consensus CDS
      CCDS71912.1
      UniProtKB/TrEMBL
      H3BL05, H3BLD9
      Related
      ENSMUSP00000135601.2, ENSMUST00000176880.2

    2. NM_146183.2 → NP_666295.2  zinc finger protein 428 isoform b

      See identical proteins and their annotated locations for NP_666295.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK139174, CX200381, CX204922
      Consensus CDS
      CCDS20952.1
      UniProtKB/Swiss-Prot
      Q4V9V1, Q8C1M2, Q8QZT0
      Related
      ENSMUSP00000071318.7, ENSMUST00000071361.13

    3. NM_175142.1 → NP_780351.1  zinc finger protein 428 isoform a

      See identical proteins and their annotated locations for NP_780351.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK139174, AV460936, CX204922
      Consensus CDS
      CCDS71912.1
      UniProtKB/TrEMBL
      H3BL05, H3BLD9
      Related
      ENSMUSP00000135750.2, ENSMUST00000177205.2

    RNA

    1. NR_110958.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses alternate splice junctions at the 5' ends of the last two exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK010415, AK139174, CX204922

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24203973..24215107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539840.5 → XP_006539903.1  zinc finger protein 428 isoform X1

      See identical proteins and their annotated locations for XP_006539903.1

      UniProtKB/TrEMBL
      H3BL05, H3BLD9

    2. XM_036152948.1 → XP_036008841.1  zinc finger protein 428 isoform X2

      UniProtKB/Swiss-Prot
      Q4V9V1, Q8C1M2, Q8QZT0

    3. XM_030242437.1 → XP_030098297.1  zinc finger protein 428 isoform X2

      UniProtKB/Swiss-Prot
      Q4V9V1, Q8C1M2, Q8QZT0

    4. XM_006539839.5 → XP_006539902.1  zinc finger protein 428 isoform X1

      See identical proteins and their annotated locations for XP_006539902.1

      UniProtKB/TrEMBL
      H3BL05, H3BLD9

    5. XM_017322156.3 → XP_017177645.1  zinc finger protein 428 isoform X2

      UniProtKB/Swiss-Prot
      Q4V9V1, Q8C1M2, Q8QZT0

    6. XM_030242439.1 → XP_030098299.1  zinc finger protein 428 isoform X2

      UniProtKB/Swiss-Prot
      Q4V9V1, Q8C1M2, Q8QZT0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C1M2.1 GenPept UniProtKB/Swiss-Prot:Q8C1M2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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