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    Imp4 IMP4, U3 small nucleolar ribonucleoprotein [ Mus musculus (house mouse) ]

    Gene ID: 27993, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Imp4provided by MGI
    Official Full Name
    IMP4, U3 small nucleolar ribonucleoproteinprovided by MGI
    Primary source
    MGI:MGI:106572
    See related
    Ensembl:ENSMUSG00000026127 AllianceGenome:MGI:106572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Wsu40e
    Summary
    Predicted to enable snoRNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit biogenesis. Predicted to be located in fibrillar center. Predicted to be part of Mpp10 complex and small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including axial musculature; extraembryonic component; submandibular gland primordium; thymus primordium; and vibrissa. Orthologous to human IMP4 (IMP U3 small nucleolar ribonucleoprotein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 19.3), ovary adult (RPKM 18.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Imp4 in Genome Data Viewer
    Location:
    1 B; 1 13.22 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34478951..34488437)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34439829..34445747)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 37233 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:34491786-34491969 Neighboring gene nuclear encoded tRNA glutamic acid 1 (anticodon TTC) Neighboring gene STARR-positive B cell enhancer ABC_E787 Neighboring gene coiled-coil domain containing 115 Neighboring gene predicted gene, 32504 Neighboring gene STARR-positive B cell enhancer mm9_chr1:34519657-34519958 Neighboring gene protein tyrosine phosphatase, non-receptor type 18 Neighboring gene predicted gene 28417

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. Granneman S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655004, Free PMC Article
    2. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables rRNA primary transcript binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Mpp10 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mpp10 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of preribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    U3 small nucleolar ribonucleoprotein protein IMP4
    Names
    IMP4, U3 small nucleolar ribonucleoprotein, homolog
    U3 snoRNP protein 4 homolog
    U3 snoRNP protein IMP4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420705.1 → NP_001407634.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC106841

    2. NM_178601.4 → NP_848716.2  U3 small nucleolar ribonucleoprotein protein IMP4 isoform 1

      See identical proteins and their annotated locations for NP_848716.2

      Status: VALIDATED

      Source sequence(s)
      AC106841
      Consensus CDS
      CCDS35536.1
      UniProtKB/Swiss-Prot
      Q3U8H6, Q8CI42, Q8VHZ7, Q9CWN6, Q9CYT5
      Related
      ENSMUSP00000027303.8, ENSMUST00000027303.14
      Conserved Domains (1) summary
      smart00879
      Location:86 → 253
      Brix; The Brix domain is found in a number of eukaryotic proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      34478951..34488437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHZ7.1 GenPept UniProtKB/Swiss-Prot:Q8VHZ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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