Dlk2 delta like non-canonical Notch ligand 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dlk2provided by MGI
Official Full Name: delta like non-canonical Notch ligand 2provided by MGI
Primary source: MGI:MGI:2146838
See related: Ensembl:ENSMUSG00000047428 AllianceGenome:MGI:2146838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DLK-2; Egfl9
Summary: Enables identical protein binding activity. Involved in regulation of fat cell differentiation. Acts upstream of or within negative regulation of Notch signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; brain; limb mesenchyme; metanephros; and musculoskeletal system. Orthologous to human DLK2 (delta like non-canonical Notch ligand 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 29.8), frontal lobe adult (RPKM 21.3) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 22.9 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (46608342..46614197)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (46297256..46303271)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation.
Title: Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation.
The expression of the Dlk2 protein in the limb bud could be detected at embryonic day 11.5.
Title: Delta-like 2 negatively regulates chondrogenic differentiation.
The expression pattern of DLK2 indicates that both proteins could play a synergistic role during cell differentiation.
Title: Similarities and differences in tissue distribution of DLK1 and DLK2 during E16.5 mouse embryogenesis.
Deletion of Dlk2 increased anxiety and depressive-like behaviors and altered the vulnerability to restraint stress.
Title: Deletion of Dlk2 increases the vulnerability to anxiety-like behaviors and impairs the anxiolytic action of alprazolam.
KLF4 mediates the transcriptional regulation of Dlk2 in response to IBMX during the early stages of adipogenesis
Title: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis.
Our results provide the first characterization of Dlk2 transcripts, map the location of the Dlk2 core promoter, and show the role of Sp1 as a key regulator of Dlk2 transcription
Title: Characterization of a proximal Sp1 response element in the mouse Dlk2 gene promoter.
Data show that DLK1 and DLK2 act as inhibitory non-canonical protein ligands for the NOTCH1 receptor that modulate NOTCH signaling.
Title: The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities.
Adipogenesis may be modulated by the coordinated expression of Dlk1 and EGFL9/Dlk2.
Title: The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as a modulator of adipogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Markers

AI413481 (e-PCR)
- UniSTS:181026

NoName (e-PCR)
- UniSTS:493303

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein delta homolog 2

Names: EGF-like protein 9; EGF-like-domain, multiple 9; delta-like 2 homolog; endothelial cell-specific protein S-1; epidermal growth factor-like protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286013.2 → NP_001272942.1 protein delta homolog 2 precursor

See identical proteins and their annotated locations for NP_001272942.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

CT009572

Consensus CDS

CCDS37634.2

UniProtKB/Swiss-Prot

B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3

Related

ENSMUSP00000128897.2, ENSMUST00000166617.8

Conserved Domains (1) summary

cd00054
Location:174 → 210

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
NM_001286028.2 → NP_001272957.1 protein delta homolog 2 precursor

See identical proteins and their annotated locations for NP_001272957.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

CT009572

Consensus CDS

CCDS37634.2

UniProtKB/Swiss-Prot

B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3

Related

ENSMUSP00000126993.2, ENSMUST00000166280.8

Conserved Domains (1) summary

cd00054
Location:174 → 210

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
NM_001414441.1 → NP_001401370.1 protein delta homolog 2 precursor

Status: VALIDATED

Source sequence(s)

CT009572

UniProtKB/Swiss-Prot

B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3
NM_001414442.1 → NP_001401371.1 protein delta homolog 2 precursor

Status: VALIDATED

Source sequence(s)

CT009572

UniProtKB/Swiss-Prot

B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3
NM_001414443.1 → NP_001401372.1 protein delta homolog 2 precursor

Status: VALIDATED

Source sequence(s)

CT009572

UniProtKB/Swiss-Prot

B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3

Related

ENSMUSP00000058470.7, ENSMUST00000061722.13
NM_001414444.1 → NP_001401373.1 protein delta homolog 2 precursor

Status: VALIDATED

Source sequence(s)

CT009572

UniProtKB/Swiss-Prot

B5B9L4, Q0IIP7, Q148N7, Q8K1E3, Q9QYP3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

46608342..46614197

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_134120.2: Suppressed sequence

Description

NM_134120.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_207666.2: Suppressed sequence

Description

NM_207666.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.