Dbnl drebrin-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dbnlprovided by MGI
Official Full Name: drebrin-likeprovided by MGI
Primary source: MGI:MGI:700006
See related: Ensembl:ENSMUSG00000020476 AllianceGenome:MGI:700006
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Abp1; SH3P7; mAbp1
Summary: Enables actin filament binding activity and protein domain specific binding activity. Involved in neuron projection morphogenesis; podosome assembly; and synapse assembly. Acts upstream of or within Rac protein signal transduction. Located in several cellular components, including lamellipodium; podosome; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and spleen. Orthologous to human DBNL (drebrin like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 46.7), spleen adult (RPKM 43.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 3.87 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (5730233..5750980)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (5788483..5800980)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the novel protein Dbnl, an actin-binding protein, controls multiple events during neuronal migration in the developing mouse cerebral cortex
Title: Drebrin-like (Dbnl) Controls Neuronal Migration via Regulating N-Cadherin Expression in the Developing Cerebral Cortex.
mAbp1 is of fundamental importance for spreading and migration under shear stress conditions, which are critical prerequisites for efficient PMN extravasation during inflammation.
Title: The mammalian actin-binding protein 1 is critical for spreading and intraluminal crawling of neutrophils under flow conditions.
These findings identify a novel role for mAbp1 in growth factor-induced dorsal ruffle formation through its interaction with WIP.[Abp1]
Title: Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation.
the genetic absence of mAbp1 almost completely abrogated firm neutrophil adhesion under physiologic shear stress conditions in vitro as well as leukocyte adhesion and extravasation in inflamed cremaster muscle venules
Title: A fundamental role of mAbp1 in neutrophils: impact on beta(2) integrin-mediated phagocytosis and adhesion in vivo.
Abp1 facilitates BCR-mediated Ag processing by simultaneously interacting with dynamin and the actin cytoskeleton.
Title: Actin-binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation.
HIP-55 has roles in T-cell proliferation, cytokine production, and immune responses
Title: HIP-55 is important for T-cell proliferation, cytokine production, and immune responses.
mAbp1 is likely to constitute a downstream effector of FYN binding protein involved in F-actin dynamics
Title: Fyn binding protein, Fyb, interacts with mammalian actin binding protein, mAbp1.
HIP-55 is a key novel component of the immunological synapse that modulates T cell activation by connecting actin cytoskeleton and TCRs to gene activation and endocytic processes
Title: Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis.
deficiency of SH3P7/mAbp1 in mouse mutants is associated with tissue abnormalities and impaired vesicle transport and their constricted physical capabilities and disturbed neuromotoric behaviour.
Title: SH3P7/mAbp1 deficiency leads to tissue and behavioral abnormalities and impaired vesicle transport.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic actin cytoskeleton	IEA Inferred from Electronic Annotation more info
enables structural constituent of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Rac protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
NOT acts_upstream_of_or_within actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
NOT acts_upstream_of_or_within actin filament severing	IDA Inferred from Direct Assay more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within barbed-end actin filament capping	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in podosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendritic spine morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
is_active_in site of polarized growth	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: drebrin-like protein

Names: SH3 domain-containing protein 7; actin-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146308.1 → NP_001139780.1 drebrin-like protein isoform 1

See identical proteins and their annotated locations for NP_001139780.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).

Source sequence(s)

AK134487, BM247511, BY293844

Consensus CDS

CCDS48746.1

UniProtKB/Swiss-Prot

Q3TG34, Q3U5X3, Q3U8I5, Q3UZ33, Q5NCI5, Q5NCI6, Q5NCI7, Q62418, Q80WP1, Q8BH56

Related

ENSMUSP00000020769.8, ENSMUST00000020769.14

Conserved Domains (3) summary

PRK13335
Location:238 → 341

PRK13335; superantigen-like protein SSL3; Reviewed

cd11281
Location:3 → 138

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

cd11960
Location:381 → 434

SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
NM_001146309.1 → NP_001139781.1 drebrin-like protein isoform 3

See identical proteins and their annotated locations for NP_001139781.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses a different splice site in its 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

AK053796, BM247511, BY293844

Consensus CDS

CCDS48747.1

UniProtKB/Swiss-Prot

Q62418

Related

ENSMUSP00000105471.2, ENSMUST00000109845.8

Conserved Domains (2) summary

cd11281
Location:3 → 138

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

cd11960
Location:377 → 430

SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
NM_013810.3 → NP_038838.1 drebrin-like protein isoform 2

See identical proteins and their annotated locations for NP_038838.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in its 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

AK140752, BM247511, BY293844

Consensus CDS

CCDS24403.1

UniProtKB/Swiss-Prot

Q62418

Related

ENSMUSP00000099992.5, ENSMUST00000102928.5

Conserved Domains (2) summary

cd11281
Location:3 → 138

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

cd11960
Location:378 → 431

SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

5730233..5750980

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156280.1 → XP_036012173.1 drebrin-like protein isoform X1

UniProtKB/Swiss-Prot

Q3TG34, Q3U5X3, Q3U8I5, Q3UZ33, Q5NCI5, Q5NCI6, Q5NCI7, Q62418, Q80WP1, Q8BH56

Conserved Domains (3) summary

PRK13335
Location:238 → 341

PRK13335; superantigen-like protein SSL3; Reviewed

cd11281
Location:3 → 138

ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

cd11960
Location:381 → 434

SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1