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    Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 16485, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcna1provided by MGI
    Official Full Name
    potassium voltage-gated channel, shaker-related subfamily, member 1provided by MGI
    Primary source
    MGI:MGI:96654
    See related
    Ensembl:ENSMUSG00000047976 AllianceGenome:MGI:96654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MBK1; Mk-1; Shak; Kv1.1; mceph; Kca1-1
    Summary
    Enables delayed rectifier potassium channel activity. Involved in several processes, including cellular response to magnesium ion; detection of mechanical stimulus involved in sensory perception; and nervous system development. Located in several cellular components, including axon; cell surface; and perikaryon. Part of voltage-gated potassium channel complex. Is active in axon initial segment. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Used to study epilepsy; episodic ataxia type 1; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in episodic ataxia type 1. Orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 30.6), cortex adult (RPKM 12.5) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Kcna1 in Genome Data Viewer
    Location:
    6 F3; 6 61.57 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126613426..126622764, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126636463..126645801, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33449 Neighboring gene predicted gene, 33496 Neighboring gene potassium voltage-gated channel, shaker-related, subfamily, member 6 Neighboring gene predicted gene, 33581 Neighboring gene STARR-seq mESC enhancer starr_17397 Neighboring gene predicted gene, 20190

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Clone Names

    • MGC124402

    Gene Ontology Provided by MGI

    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in action potential  
    involved_in axon development  
    involved_in brain development PubMed 
    involved_in cell communication by electrical coupling  
    involved_in cell communication by electrical coupling  
    involved_in cellular response to magnesium ion PubMed 
    involved_in cerebral cortex development  
    involved_in corpus callosum development  
    involved_in detection of mechanical stimulus involved in sensory perception of pain PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception of touch PubMed 
    involved_in hippocampus development PubMed 
    involved_in magnesium ion homeostasis  
    involved_in magnesium ion homeostasis  
    involved_in membrane repolarization during action potential PubMed 
    involved_in membrane repolarization during action potential  
    involved_in neuroblast proliferation PubMed 
    involved_in neuromuscular process PubMed 
    involved_in neuromuscular process  
    involved_in neuronal action potential PubMed 
    involved_in neuronal action potential  
    involved_in neuronal action potential  
    involved_in neuronal signal transduction  
    involved_in neuronal signal transduction  
    involved_in optic nerve development  
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport PubMed 
    involved_in potassium ion transmembrane transport  
    involved_in protein homooligomerization  
    involved_in protein localization  
    involved_in protein localization  
    involved_in regulation of membrane potential  
    involved_in regulation of membrane potential  
    involved_in regulation of muscle contraction  
    involved_in regulation of muscle contraction  
    involved_in regulation of postsynaptic membrane potential  
    involved_in regulation of presynaptic membrane potential  
    involved_in startle response PubMed 
    involved_in startle response  
    Items 1 - 25 of 38
    Items 1 - 20 of 46
    Component Evidence Code Pubs
    located_in anchoring junction  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in axon PubMed 
    is_active_in axon initial segment PubMed 
    located_in axon terminus PubMed 
    located_in calyx of Held  
    is_active_in calyx of Held  
    located_in cell junction PubMed 
    located_in cell surface PubMed 
    located_in cell surface  
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in cytosol  
    is_active_in dendrite  
    located_in dendrite PubMed 
    located_in dendrite  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    is_active_in juxtaparanode region of axon  
    located_in juxtaparanode region of axon PubMed 
    located_in juxtaparanode region of axon  
    is_active_in membrane  
    is_active_in neuronal cell body  
    located_in neuronal cell body PubMed 
    located_in neuronal cell body  
    is_active_in paranode region of axon  
    located_in paranode region of axon PubMed 
    located_in paranode region of axon  
    located_in paranode region of axon  
    located_in perikaryon PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in postsynaptic membrane  
    is_active_in postsynaptic membrane  
    part_of potassium channel complex  
    is_active_in presynaptic membrane  
    located_in presynaptic membrane  
    located_in presynaptic membrane  
    is_active_in synapse  
    located_in synapse PubMed 
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex PubMed 
    part_of voltage-gated potassium channel complex  
    Items 1 - 20 of 46

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily A member 1
    Names
    MKI
    brain potassium channel protein-1
    megencephaly
    voltage-gated potassium channel subunit Kv1.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010595.3NP_034725.3  potassium voltage-gated channel subfamily A member 1

      See identical proteins and their annotated locations for NP_034725.3

      Status: VALIDATED

      Source sequence(s)
      AC079438
      Consensus CDS
      CCDS20555.1
      UniProtKB/Swiss-Prot
      P16388
      UniProtKB/TrEMBL
      Q2KHP0
      Related
      ENSMUSP00000055225.4, ENSMUST00000055168.5
      Conserved Domains (2) summary
      cl38908
      Location:37163
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:166418
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      126613426..126622764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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