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    Vps37d vacuolar protein sorting 37D [ Mus musculus (house mouse) ]

    Gene ID: 194309, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Vps37dprovided by MGI
    Official Full Name
    vacuolar protein sorting 37Dprovided by MGI
    Primary source
    MGI:MGI:2159402
    See related
    Ensembl:ENSMUSG00000043614 AllianceGenome:MGI:2159402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wbscr24
    Summary
    Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in late endosome membrane. Predicted to be part of ESCRT I complex. Is expressed in brain; cartilage; spinal cord; testis; and trachea. Orthologous to human VPS37D (VPS37D subunit of ESCRT-I). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 17.3), CNS E18 (RPKM 15.8) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vps37d in Genome Data Viewer
    Location:
    5 G2; 5 74.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135101751..135107197, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135072899..135078326, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25492 Neighboring gene BUD23, rRNA methyltransferase and ribosome maturation factor Neighboring gene STARR-positive B cell enhancer ABC_E673 Neighboring gene DnaJ heat shock protein family (Hsp40) member C30 Neighboring gene STARR-seq mESC enhancer starr_14566 Neighboring gene MLX interacting protein-like Neighboring gene STARR-positive B cell enhancer ABC_E855 Neighboring gene STARR-positive B cell enhancer ABC_E280 Neighboring gene transducin (beta)-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC51411

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ESCRT I complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 37D
    Names
    ESCRT-I complex subunit VPS37D
    Williams-Beuren syndrome chromosome region 24 homolog
    Williams-Beuren syndrome critical region protein 24
    williams-Beuren syndrome region protein 24 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199677.2 → NP_001186606.1  vacuolar protein sorting-associated protein 37D isoform 1

      See identical proteins and their annotated locations for NP_001186606.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC084109
      Consensus CDS
      CCDS57388.1
      UniProtKB/Swiss-Prot
      Q80UX4, Q810I0, Q8C1V8
      Related
      ENSMUSP00000063762.5, ENSMUST00000067935.11
      Conserved Domains (2) summary
      PTZ00449
      Location:198 → 259
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam07200
      Location:22 → 165
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    2. NM_177574.5 → NP_808242.1  vacuolar protein sorting-associated protein 37D isoform 2

      See identical proteins and their annotated locations for NP_808242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC084109
      Consensus CDS
      CCDS19733.1
      UniProtKB/Swiss-Prot
      Q810I0
      Related
      ENSMUSP00000075559.3, ENSMUST00000076203.3
      Conserved Domains (1) summary
      pfam07200
      Location:22 → 92
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    RNA

    1. NR_189596.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084109

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135101751..135107197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240872.4 → XP_011239174.1  vacuolar protein sorting-associated protein 37D isoform X1

      Conserved Domains (2) summary
      PTZ00449
      Location:191 → 252
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam07200
      Location:39 → 158
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    RNA

    1. XR_001784645.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810I0.2 GenPept UniProtKB/Swiss-Prot:Q810I0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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