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    Dnah10 dynein, axonemal, heavy chain 10 [ Mus musculus (house mouse) ]

    Gene ID: 56087, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnah10provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 10provided by MGI
    Primary source
    MGI:MGI:1860299
    See related
    Ensembl:ENSMUSG00000038011 AllianceGenome:MGI:1860299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnahc10
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to act upstream of or within cilium movement. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium. Is expressed in embryo. Used to study spermatogenic failure. Human ortholog(s) of this gene implicated in spermatogenic failure 56. Orthologous to human DNAH10 (dynein axonemal heavy chain 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 4.7), lung adult (RPKM 1.5) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Dnah10 in Genome Data Viewer
    Location:
    5 F- G1.1; 5 63.78 cM
    Exon count:
    80
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124802149..124911372)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124725085..124834308)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10353 Neighboring gene STARR-seq mESC enhancer starr_14344 Neighboring gene tectonic family member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr5:125079413-125079714 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit A2 Neighboring gene coiled-coil domain containing 92 Neighboring gene zinc finger protein 664

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice. Wang R, et al. Front Med, 2023 Oct. PMID 37314648
    2. Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice. Tu C, et al. Am J Hum Genet, 2021 Aug 5. PMID 34237282, Free PMC Article
    3. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Neesen J, et al. Gene, 1997 Oct 24. PMID 9373155
    4. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice.
      Title: Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice.
    2. Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice.
      Title: Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium movement IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inner dynein arm ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein axonemal heavy chain 10
    Names
    dynein, axon, heavy chain 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019536.1 → NP_062409.1  dynein axonemal heavy chain 10

      Status: PROVISIONAL

      Source sequence(s)
      AC164649, AC242457
      Consensus CDS
      CCDS51649.1
      UniProtKB/TrEMBL
      D3YYQ8, F7ABZ6
      Related
      ENSMUSP00000062995.9, ENSMUST00000058440.12
      Conserved Domains (6) summary
      pfam03028
      Location:3884 → 4580
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:306 → 878
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1377 → 1780
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3165 → 3498
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3527 → 3743
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1914 → 2142
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124802149..124911372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165323.1 → XP_036021216.1  dynein axonemal heavy chain 10 isoform X1

      UniProtKB/TrEMBL
      F7ABZ6
      Conserved Domains (6) summary
      COG5245
      Location:563 → 3524
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:4 → 169
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:665 → 1070
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1205 → 1531
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2184 → 2443
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:3581 → 3879
      Dynein_C; Dynein heavy chain C-terminal domain

    2. XM_036165324.1 → XP_036021217.1  dynein axonemal heavy chain 10 isoform X2

      UniProtKB/TrEMBL
      F7ABZ6

    3. XM_036165326.1 → XP_036021219.1  dynein axonemal heavy chain 10 isoform X3

    4. XM_036165325.1 → XP_036021218.1  dynein axonemal heavy chain 10 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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