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    Map7d1 MAP7 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 245877, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Map7d1provided by MGI
    Official Full Name
    MAP7 domain containing 1provided by MGI
    Primary source
    MGI:MGI:2384297
    See related
    Ensembl:ENSMUSG00000028849 AllianceGenome:MGI:2384297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rprc1; Parcc1; Mtap7d1; mKIAA1187
    Summary
    Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in cytoplasm and spindle. Predicted to be active in microtubule cytoskeleton. Is expressed in dorsal root ganglion; facial ganglion; glossopharyngeal ganglion; trigeminal ganglion; and trigeminal nerve. Orthologous to human MAP7D1 (MAP7 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 69.4), CNS E11.5 (RPKM 66.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map7d1 in Genome Data Viewer
    Location:
    4 D2.2; 4 60.16 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126125960..126150112, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126232167..126256319, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125839584-125839767 Neighboring gene SH3 domain containing 21 Neighboring gene STARR-seq mESC enhancer starr_11390 Neighboring gene thyroid hormone receptor associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_11391 Neighboring gene STARR-seq mESC enhancer starr_11392 Neighboring gene predicted gene, 25323 Neighboring gene STARR-positive B cell enhancer ABC_E6217 Neighboring gene STARR-positive B cell enhancer ABC_E2122 Neighboring gene trafficking protein particle complex 3 Neighboring gene predicted gene, 54258 Neighboring gene collagen, type VIII, alpha 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DCLK1 phosphorylates the microtubule-associated protein MAP7D1 to promote axon elongation in cortical neurons. Koizumi H, et al. Dev Neurobiol, 2017 Apr. PMID 27503845
    2. Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. McFarland MA, et al. Mol Cell Proteomics, 2008 Nov. PMID 18614564, Free PMC Article
    3. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27585, MGC28498

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MAP7 domain-containing protein 1
    Names
    arginine/proline rich coiled-coil 1
    microtubule-associated protein 7 domain containing 1
    proline arginine rich coiled coil 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145970.1 → NP_001139442.1  MAP7 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has several in-frame differences in its coding sequence compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BM944422, BQ713545, BU053928, CA750559, CK617787, CO043023
      Consensus CDS
      CCDS51302.1
      UniProtKB/TrEMBL
      A2AJI1
      Related
      ENSMUSP00000101738.3, ENSMUST00000106132.3
      Conserved Domains (1) summary
      pfam05672
      Location:517 → 663
      MAP7; MAP7 (E-MAP-115) family

    2. NM_001347198.1 → NP_001334127.1  MAP7 domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL732624
      Consensus CDS
      CCDS84793.1
      UniProtKB/TrEMBL
      A8Y5P4
      Related
      ENSMUSP00000113250.2, ENSMUST00000122129.8

    3. NM_001379090.1 → NP_001366019.1  MAP7 domain-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL732624
      Conserved Domains (3) summary
      PTZ00121
      Location:90 → 223
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:314 → 603
      PHA03247; large tegument protein UL36; Provisional
      pfam05672
      Location:588 → 732
      MAP7; MAP7 (E-MAP-115) family

    4. NM_001379091.1 → NP_001366020.1  MAP7 domain-containing protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL732624
      Conserved Domains (3) summary
      PTZ00121
      Location:90 → 223
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:298 → 497
      PHA03247; large tegument protein UL36; Provisional
      pfam05672
      Location:556 → 700
      MAP7; MAP7 (E-MAP-115) family

    5. NM_001379092.1 → NP_001366021.1  MAP7 domain-containing protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL732624
      Conserved Domains (3) summary
      PTZ00121
      Location:90 → 223
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:280 → 569
      PHA03247; large tegument protein UL36; Provisional
      pfam05672
      Location:554 → 698
      MAP7; MAP7 (E-MAP-115) family

    6. NM_001379093.1 → NP_001366022.1  MAP7 domain-containing protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL732624
      Conserved Domains (3) summary
      PTZ00121
      Location:90 → 223
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:277 → 566
      PHA03247; large tegument protein UL36; Provisional
      pfam05672
      Location:551 → 695
      MAP7; MAP7 (E-MAP-115) family

    7. NM_001379094.1 → NP_001366023.1  MAP7 domain-containing protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL732624
      Conserved Domains (3) summary
      PTZ00121
      Location:90 → 223
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:264 → 463
      PHA03247; large tegument protein UL36; Provisional
      pfam05672
      Location:522 → 666
      MAP7; MAP7 (E-MAP-115) family

    8. NM_144941.3 → NP_659190.3  MAP7 domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_659190.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BM944422, BM944941, BU053928, CA750559, CK617787, CO043023, CV563343
      Consensus CDS
      CCDS18646.1
      UniProtKB/Swiss-Prot
      A2AJI0, Q80TI3, Q8CIL3, Q8VCG2, Q91YQ4
      Related
      ENSMUSP00000054338.9, ENSMUST00000061143.15
      Conserved Domains (3) summary
      PTZ00121
      Location:90 → 223
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:317 → 606
      PHA03247; large tegument protein UL36; Provisional
      pfam05672
      Location:591 → 735
      MAP7; MAP7 (E-MAP-115) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      126125960..126150112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AJI0.1 GenPept UniProtKB/Swiss-Prot:A2AJI0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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