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    Pheta2 PH domain containing endocytic trafficking adaptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 338368, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pheta2provided by MGI
    Official Full Name
    PH domain containing endocytic trafficking adaptor 2provided by MGI
    Primary source
    MGI:MGI:2443609
    See related
    Ensembl:ENSMUSG00000049687 AllianceGenome:MGI:2443609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ses2; Fam109b; IPIP27B; C920005C14Rik
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Predicted to be located in clathrin-coated vesicle. Predicted to be active in early endosome; recycling endosome; and trans-Golgi network. Orthologous to human PHETA2 (PH domain containing endocytic trafficking adaptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14.5 (RPKM 14.4), liver E14 (RPKM 13.8) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pheta2 in Genome Data Viewer
    Location:
    15 E1; 15 38.56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82223148..82229911)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82338927..82345710)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene WBP2 N-terminal like Neighboring gene N-acetyl galactosaminidase, alpha Neighboring gene STARR-seq mESC enhancer starr_39293 Neighboring gene nuclear encoded rRNA 5S 41 Neighboring gene single-pass membrane protein with aspartate rich tail 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82192158-82192359 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1. Swan LE, et al. Proc Natl Acad Sci U S A, 2010 Feb 23. PMID 20133602, Free PMC Article
    2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sesquipedalian-2
    Names
    27 kDa inositol polyphosphate phosphatase interacting protein B
    family with sequence similarity 109, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357717.1 → NP_001344646.1  sesquipedalian-2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC104325
      Consensus CDS
      CCDS27687.1
      UniProtKB/Swiss-Prot
      Q14B98, Q8BUL8
      UniProtKB/TrEMBL
      A0A0R4J1Z2
      Related
      ENSMUSP00000124703.2, ENSMUST00000161178.2
      Conserved Domains (1) summary
      cl17171
      Location:11 → 138
      PH-like; Pleckstrin homology-like domain

    2. NM_177391.4 → NP_796365.1  sesquipedalian-2

      See identical proteins and their annotated locations for NP_796365.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK083325, BY775160, CJ162278
      Consensus CDS
      CCDS27687.1
      UniProtKB/Swiss-Prot
      Q14B98, Q8BUL8
      UniProtKB/TrEMBL
      A0A0R4J1Z2
      Related
      ENSMUSP00000060598.3, ENSMUST00000050349.3
      Conserved Domains (1) summary
      cl17171
      Location:11 → 138
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82223148..82229911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245682.3 → XP_011243984.1  sesquipedalian-2 isoform X1

      See identical proteins and their annotated locations for XP_011243984.1

      UniProtKB/Swiss-Prot
      Q14B98, Q8BUL8
      UniProtKB/TrEMBL
      A0A0R4J1Z2
      Conserved Domains (1) summary
      cl17171
      Location:11 → 138
      PH-like; Pleckstrin homology-like domain

    2. XM_011245681.4 → XP_011243983.1  sesquipedalian-2 isoform X1

      See identical proteins and their annotated locations for XP_011243983.1

      UniProtKB/Swiss-Prot
      Q14B98, Q8BUL8
      UniProtKB/TrEMBL
      A0A0R4J1Z2
      Conserved Domains (1) summary
      cl17171
      Location:11 → 138
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14B98.1 GenPept UniProtKB/Swiss-Prot:Q14B98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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