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    NPIPB5 nuclear pore complex interacting protein family member B5 [ Homo sapiens (human) ]

    Gene ID: 100132247, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NPIPB5provided by HGNC
    Official Full Name
    nuclear pore complex interacting protein family member B5provided by HGNC
    Primary source
    HGNC:HGNC:37233
    See related
    Ensembl:ENSG00000243716 AllianceGenome:HGNC:37233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in skin (RPKM 35.9), bone marrow (RPKM 26.2) and 24 other tissues See more
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    Genomic context

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    See NPIPB5 in Genome Data Viewer
    Location:
    16p12.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (22503599..22536535)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (22781607..22814310)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22514920..22547856)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RRN3 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:22458379-22458880 Neighboring gene SMG1 pseudogene 1 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:22510885-22511742 Neighboring gene uncharacterized LOC105371131 Neighboring gene OTOA pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:22585646-22585849 Neighboring gene uncharacterized LOC112268175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:22593503-22594003

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Divergent origins and concerted expansion of two segmental duplications on chromosome 16. Eichler EE, et al. J Hered, 2001 Nov-Dec. PMID 11948212
    2. A proteome-scale map of the SARS-CoV-2-human contactome. Kim DK, et al. Nat Biotechnol, 2023 Jan. PMID 36217029, Free PMC Article
    3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Antoniali G, et al. Nat Commun, 2017 Oct 6. PMID 28986522, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ61599, MGC70907, DKFZp564D113

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex-interacting protein family member B5
    Names
    nuclear pore complex interacting protein related

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135865.3 → NP_001129337.1  nuclear pore complex-interacting protein family member B5

      See identical proteins and their annotated locations for NP_001129337.1

      Status: VALIDATED

      Source sequence(s)
      AC106788
      Consensus CDS
      CCDS45443.1
      UniProtKB/Swiss-Prot
      A8MRT5, B4DK13
      Conserved Domains (3) summary
      PHA03307
      Location:871 → 1131
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam06409
      Location:46 → 303
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl17068
      Location:2 → 41
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. NM_001395849.1 → NP_001382778.1  nuclear pore complex-interacting protein family member B5

      Status: VALIDATED

      Source sequence(s)
      AC106788
      Consensus CDS
      CCDS45443.1
      UniProtKB/Swiss-Prot
      A8MRT5, B4DK13
      Related
      ENSP00000440703.1, ENST00000424340.7
      Conserved Domains (3) summary
      PHA03307
      Location:871 → 1131
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam06409
      Location:46 → 303
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl17068
      Location:2 → 41
      AFD_class_I; Adenylate forming domain, Class I superfamily

    3. NM_001395850.1 → NP_001382779.1  nuclear pore complex-interacting protein family member B5

      Status: VALIDATED

      Source sequence(s)
      AC106788
      Consensus CDS
      CCDS45443.1
      UniProtKB/Swiss-Prot
      A8MRT5, B4DK13
      Related
      ENSP00000430633.1, ENST00000517539.6
      Conserved Domains (3) summary
      PHA03307
      Location:871 → 1131
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam06409
      Location:46 → 303
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl17068
      Location:2 → 41
      AFD_class_I; Adenylate forming domain, Class I superfamily

    4. NM_001395851.1 → NP_001382780.1  nuclear pore complex-interacting protein family member B5

      Status: VALIDATED

      Source sequence(s)
      AC106788
      Consensus CDS
      CCDS45443.1
      UniProtKB/Swiss-Prot
      A8MRT5, B4DK13
      Conserved Domains (3) summary
      PHA03307
      Location:871 → 1131
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam06409
      Location:46 → 303
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl17068
      Location:2 → 41
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      22503599..22536535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_017852933.1 Reference GRCh38.p14 PATCHES

      Range
      568502..601442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      22781607..22814310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MRT5.3 GenPept UniProtKB/Swiss-Prot:A8MRT5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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