PLAAT3 phospholipase A and acyltransferase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLAAT3provided by HGNC
Official Full Name: phospholipase A and acyltransferase 3provided by HGNC
Primary source: HGNC:HGNC:17825
See related: Ensembl:ENSG00000176485 MIM:613867; AllianceGenome:HGNC:17825
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AdPLA; FPLD9; HRSL3; HRASLS3; HREV107; PLA2G16; PLAAT-3; H-REV107; HREV107-1; HREV107-3; H-REV107-1
Summary: Enables N-acyltransferase activity; lipid binding activity; and phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process. Predicted to be located in several cellular components, including lysosome; nuclear envelope; and peroxisome. Predicted to be active in cytoplasm. Biomarker of seminoma. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in fat (RPKM 173.9), testis (RPKM 32.8) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q12.3-q13.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (63574462..63616927, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (63563752..63606267, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (63341934..63381909, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer.
Title: PLA2G16 is a mutant p53/KLF5 transcriptional target and promotes glycolysis of pancreatic cancer.
Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease.
Title: Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease.
PLA2G16 methylation defines an extensive field defect in histologically normal prostate tissue associated with PC.
Title: Screening of urine identifies PLA2G16 as a field defect methylation biomarker for prostate cancer detection.
PLA2G16 SNPs are associated with the colorectal cancer risk in the Chinese population.
Title: Relationship between polymorphisms of the lipid metabolism-related gene PLA2G16 and risk of colorectal cancer in the Chinese population.
study uncovers two competing processes triggered by Picornaviridae virus entry: activation of a pore-activated clearance pathway and recruitment of a PLA2G16 phospholipase to enable genome release
Title: PLA2G16 represents a switch between entry and clearance of Picornaviridae.
Demonstrate increased PLA2G16 expression activates the MAPK pathway to enhance osteosarcoma metastasis.
Title: PLA2G16 promotes osteosarcoma metastasis and drug resistance via the MAPK pathway.
our results revealed that H-rev107 is also involved in lipid accumulation in liver cells through the POR pathway via its PLA2 activity.
Title: H-rev107 Regulates Cytochrome P450 Reductase Activity and Increases Lipid Accumulation.
Results show that osteosarcoma patients with metastasis showed higher expression of PLA2G16 at both the mRNA and protein levels and shorter overall survival suggesting it as significant prognostic factor for poor outcome.
Title: PLA2G16 Expression in Human Osteosarcoma Is Associated with Pulmonary Metastasis and Poor Prognosis.
suggest a novel regulatory mechanism for peroxisome biogenesis through the interaction between Pex19p and PLA/AT-3
Title: Interaction of Phospholipase A/Acyltransferase-3 with Pex19p: A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES.
the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death.
Title: Structural and functional characterization of tumor suppressors TIG3 and H-REV107.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Lipodystrophy, familial partial, type 9 MedGen: C5882746 OMIM: 620683 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482585

G60399 (e-PCR)
- UniSTS:137505

RH80558 (e-PCR)
- UniSTS:91270

D11S1883 (e-PCR)
- UniSTS:77961

STS-X92814 (e-PCR)
- UniSTS:3820

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyltransferase activity	TAS Traceable Author Statement more info
enables calcium-dependent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables calcium-independent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	EXP Inferred from Experiment more info	PubMed
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in N-acylphosphatidylethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acylphosphatidylethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ether lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lens fiber cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in organelle disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in peroxisome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylethanolamine acyl-chain remodeling	TAS Traceable Author Statement more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of adipose tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in triglyceride metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phospholipase A and acyltransferase 3

Names: Ca-independent phospholipase A1/2; H-rev 107 protein homolog; HRAS-like suppressor 1; HRAS-like suppressor 3; adipose-specific PLA2; adipose-specific phospholipase A2; group XVI phospholipase A1/A2; group XVI phospholipase A2; phospholipase A/acyltransferase-3; phospholipase A2 group XVI; renal carcinoma antigen NY-REN-65

NP_001121675.1

EC 3.1.1.32

EC 3.1.1.4

NP_009000.2

EC 3.1.1.32

EC 3.1.1.4

XP_011543043.1

EC 3.1.1.32

EC 3.1.1.4

XP_054223515.1

EC 3.1.1.32

EC 3.1.1.4

XP_054223516.1

EC 3.1.1.32

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128203.2 → NP_001121675.1 phospholipase A and acyltransferase 3

See identical proteins and their annotated locations for NP_001121675.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.

Source sequence(s)

AI374456, AI590735, BG719903, CK003948

Consensus CDS

CCDS8047.1

UniProtKB/Swiss-Prot

B2R7Q4, B7XAK5, P53816, Q3SYI3, Q9HDD1

Related

ENSP00000389124.1, ENST00000415826.3

Conserved Domains (1) summary

pfam04970
Location:19 → 125

LRAT; Lecithin retinol acyltransferase
NM_007069.3 → NP_009000.2 phospholipase A and acyltransferase 3

See identical proteins and their annotated locations for NP_009000.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform.

Source sequence(s)

AI374456, AI590735, AK313075, AU099540

Consensus CDS

CCDS8047.1

UniProtKB/Swiss-Prot

B2R7Q4, B7XAK5, P53816, Q3SYI3, Q9HDD1

Related

ENSP00000320337.5, ENST00000323646.9

Conserved Domains (1) summary

pfam04970
Location:19 → 125

LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

63574462..63616927 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011544741.2 → XP_011543043.1 phospholipase A and acyltransferase 3 isoform X1

See identical proteins and their annotated locations for XP_011543043.1

Conserved Domains (1) summary

pfam04970
Location:35 → 140

LRAT; Lecithin retinol acyltransferase

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

63563752..63606267 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054367540.1 → XP_054223515.1 phospholipase A and acyltransferase 3 isoform X1
XM_054367541.1 → XP_054223516.1 phospholipase A and acyltransferase 3 isoform X2

UniProtKB/Swiss-Prot

B2R7Q4, B7XAK5, P53816, Q3SYI3, Q9HDD1