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    ELK3 ETS transcription factor ELK3 [ Homo sapiens (human) ]

    Gene ID: 2004, updated on 25-Dec-2024

    Summary

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    Official Symbol
    ELK3provided by HGNC
    Official Full Name
    ETS transcription factor ELK3provided by HGNC
    Primary source
    HGNC:HGNC:3325
    See related
    Ensembl:ENSG00000111145 MIM:600247; AllianceGenome:HGNC:3325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERP; NET; SAP2; SAP-2
    Summary
    This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Annotation information
    Note: NET is an alias on both SLC6A2 (Gene ID: 6530, "norepinephrine transporter") and ELK3 (Gene ID: 2004). [01 Jun 2018]
    Expression
    Ubiquitous expression in spleen (RPKM 23.7), endometrium (RPKM 22.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ELK3 in Genome Data Viewer
    Location:
    12q23.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (96194375..96269824)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (96168506..96244027)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (96588153..96663602)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369923 Neighboring gene RNA, 7SL, cytoplasmic 88, pseudogene Neighboring gene Sharpr-MPRA regulatory region 6189 Neighboring gene long intergenic non-protein coding RNA 2452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96603880-96604402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6826 Neighboring gene uncharacterized LOC124902991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96628784-96629768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96631810-96632310 Neighboring gene cyclin dependent kinase 17 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96709352-96709984 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96709985-96710615 Neighboring gene RNA, U4 small nuclear 24, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6830 Neighboring gene RN7SK pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ETS transcription factor ELK3 in human cancers: An emerging therapeutic target. Al-Hawary SIS, et al. Pathol Res Pract, 2023 Aug. PMID 37542863
    2. ELK3 expressed in lymphatic endothelial cells promotes breast cancer progression and metastasis through exosomal miRNAs. Kim KS, et al. Sci Rep, 2019 Jun 10. PMID 31182803, Free PMC Article
    3. The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock. Ducret C, et al. Mol Cell Biol, 1999 Oct. PMID 10490644, Free PMC Article
    4. Growth inhibitory effect of the ternary complex factor Net on human pancreatic carcinoma cell lines. Li B, et al. Tohoku J Exp Med, 2008 Oct. PMID 18832796
    5. Molecular and clinical features of a potential immunotherapy target ELK3 in glioma. Xu H, et al. Medicine (Baltimore), 2022 Jul 29. PMID 35905257, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance.
      Title: ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance.
    2. ELK3-ID4 axis governs the metastatic features of triple negative breast cancer.
      Title: ELK3-ID4 axis governs the metastatic features of triple negative breast cancer.
    3. ETS transcription factor ELK3 in human cancers: An emerging therapeutic target.
      Title: ETS transcription factor ELK3 in human cancers: An emerging therapeutic target.
    4. ELK3 Targeting AEG1 Promotes Migration and Invasion of Ovarian Cancer Cells under Hypoxia.
      Title: ELK3 Targeting AEG1 Promotes Migration and Invasion of Ovarian Cancer Cells under Hypoxia.
    5. ELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer.
      Title: ELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer.
    6. Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD).
      Title: Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD).
    7. Circular RNA hsa_circ_0000144 aggravates ovarian Cancer progression by regulating ELK3 via sponging miR-610.
      Title: Circular RNA hsa_circ_0000144 aggravates ovarian Cancer progression by regulating ELK3 via sponging miR-610.
    8. Molecular and clinical features of a potential immunotherapy target ELK3 in glioma.
      Title: Molecular and clinical features of a potential immunotherapy target ELK3 in glioma.
    9. ELK3 Controls Gastric Cancer Cell Migration and Invasion by Regulating ECM Remodeling-Related Genes.
      Title: ELK3 Controls Gastric Cancer Cell Migration and Invasion by Regulating ECM Remodeling-Related Genes.
    10. [Expression characteristics and functional analysis of ELK3 in gastric cancer].
      Title: [Expression characteristics and functional analysis of ELK3 in gastric cancer].
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables purine-rich negative regulatory element binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ETS domain-containing protein Elk-3
    Names
    ELK3, ETS transcription factor
    ELK3, ETS-domain protein (SRF accessory protein 2)
    ETS-related protein ERP
    ETS-related protein NET
    SRF accessory protein 2
    serum response factor accessory protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303511.2 → NP_001290440.1  ETS domain-containing protein Elk-3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks several exon in the 5' UTR and coding region and uses an alternate 5' most exon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC008149, AL705041, AW575797

    2. NM_001413760.1 → NP_001400689.1  ETS domain-containing protein Elk-3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008149
      UniProtKB/Swiss-Prot
      B2R6S6, P41970, Q6FG57, Q6GU29, Q9UD17

    3. NM_001413761.1 → NP_001400690.1  ETS domain-containing protein Elk-3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008149
      UniProtKB/Swiss-Prot
      B2R6S6, P41970, Q6FG57, Q6GU29, Q9UD17

    4. NM_001413762.1 → NP_001400691.1  ETS domain-containing protein Elk-3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC008149

    5. NM_001413763.1 → NP_001400692.1  ETS domain-containing protein Elk-3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC008149

    6. NM_001413764.1 → NP_001400693.1  ETS domain-containing protein Elk-3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC008149

    7. NM_001413765.1 → NP_001400694.1  ETS domain-containing protein Elk-3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC008149

    8. NM_005230.4 → NP_005221.2  ETS domain-containing protein Elk-3 isoform 1

      See identical proteins and their annotated locations for NP_005221.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AC008149, AK312694, AW575797, DA754301
      Consensus CDS
      CCDS9060.1
      UniProtKB/Swiss-Prot
      B2R6S6, P41970, Q6FG57, Q6GU29, Q9UD17
      Related
      ENSP00000228741.3, ENST00000228741.8
      Conserved Domains (1) summary
      smart00413
      Location:19 → 88
      ETS; erythroblast transformation specific domain

    RNA

    1. NR_182212.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008149

    2. NR_182213.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008149

    3. NR_182214.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008149

    4. NR_182215.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008149

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      96194375..96269824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      96168506..96244027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41970.2 GenPept UniProtKB/Swiss-Prot:P41970

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools