Ccr1 C-C motif chemokine receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccr1provided by MGI
Official Full Name: C-C motif chemokine receptor 1provided by MGI
Primary source: MGI:MGI:104618
See related: Ensembl:ENSMUSG00000025804 AllianceGenome:MGI:104618
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cmkbr1; Mip-1a-R
Summary: Enables C-C chemokine receptor activity. Involved in negative regulation of innate immune response. Acts upstream of or within inflammatory response; leukocyte chemotaxis; and myeloid cell differentiation. Predicted to be located in neuronal cell body and plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including aorta-gonad-mesonephros; extraembryonic component; limb; and liver. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif chemokine receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E18 (RPKM 2.5), large intestine adult (RPKM 2.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 75.05 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (123762163..123768729, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (123962126..123968692, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synergistic antitumor activity by dual blockade of CCR1 and CXCR2 expressed on myeloid cells within the tumor microenvironment.
Title: Synergistic antitumor activity by dual blockade of CCR1 and CXCR2 expressed on myeloid cells within the tumor microenvironment.
Chemokine receptor CCR1 regulates macrophage activation through mTORC1 signaling in nonalcoholic steatohepatitis.
Title: Chemokine receptor CCR1 regulates macrophage activation through mTORC1 signaling in nonalcoholic steatohepatitis.
Inhibition of CCR1 attenuates neuroinflammation via the JAK2/STAT3 signaling pathway after subarachnoid hemorrhage.
Title: Inhibition of CCR1 attenuates neuroinflammation via the JAK2/STAT3 signaling pathway after subarachnoid hemorrhage.
The Chemokine Receptor CCR1 Mediates Microglia Stimulated Glioma Invasion.
Title: The Chemokine Receptor CCR1 Mediates Microglia Stimulated Glioma Invasion.
Eosinophil-derived chemokine (hCCL15/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation.
Title: Eosinophil-derived chemokine (hCCL15/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation.
CCR1 Activation Promotes Neuroinflammation Through CCR1/TPR1/ERK1/2 Signaling Pathway After Intracerebral Hemorrhage in Mice.
Title: CCR1 Activation Promotes Neuroinflammation Through CCR1/TPR1/ERK1/2 Signaling Pathway After Intracerebral Hemorrhage in Mice.
Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1.
Title: Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1.
Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis.
Title: Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis.
Localization-Specific Expression of CCR1 and CCR5 by Mast Cell Progenitors.
Title: Localization-Specific Expression of CCR1 and CCR5 by Mast Cell Progenitors.
These results show that the up-regulation of CCR1(+) cells was related to the control of systemic inflammation of Behcet's disease in mouse models.
Title: The role of CCR1 and therapeutic effects of anti-CCL3 antibody in herpes simplex virus-induced Behçet's disease mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables C-C chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables chemokine (C-C motif) ligand 5 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 5 binding	ISO Inferred from Sequence Orthology more info
enables chemokine (C-C motif) ligand 7 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 7 binding	ISO Inferred from Sequence Orthology more info
enables chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leukocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: C-C chemokine receptor type 1

Names: C-C CKR-1; CC-CKR-1; CCR-1; MIP-1 alpha R; MIP-1 alphaR; MIP-1alpha-R; RANTES-R; chemokine (C-C motif) receptor 1; chemokine (C-C) receptor 1; macrophage inflammatory protein 1-alpha receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.