Rab29 RAB29, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab29provided by MGI
Official Full Name: RAB29, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:2385107
See related: Ensembl:ENSMUSG00000026433 AllianceGenome:MGI:2385107
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rab7l1
Summary: Enables GTP binding activity. Involved in cilium assembly and protein localization to ciliary membrane. Acts upstream of or within Golgi organization. Located in Golgi apparatus and vesicle. Orthologous to human RAB29 (RAB29, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 9.9), subcutaneous fat pad adult (RPKM 7.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.21 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (131795004..131801003)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (131867210..131872887)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity.
Title: Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity.
LRRK2 functions together with a second Parkinson's disease-associated gene, RAB7L1, within an evolutionarily conserved genetic module in diverse cellular contexts.
Title: LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular detoxification	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in modulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in protein localization to ciliary membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in regulation of retrograde transport, endosome to Golgi	NAS Non-traceable Author Statement more info	PubMed
involved_in response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular vesicle	ISO Inferred from Sequence Orthology more info
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info
located_in vacuole	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras-related protein Rab-7L1

Names: RAB7, member RAS oncogene family-like 1; rab-7-like protein 1; ras-related protein Rab-29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421410.1 → NP_001408339.1 ras-related protein Rab-7L1 isoform 1

Status: VALIDATED

Source sequence(s)

AC161805

UniProtKB/TrEMBL

E9QLQ7

Related

ENSMUSP00000108005.2, ENSMUST00000112386.8
NM_001421411.1 → NP_001408340.1 ras-related protein Rab-7L1 isoform 2

Status: VALIDATED

Source sequence(s)

AC161805
NM_001421412.1 → NP_001408341.1 ras-related protein Rab-7L1 isoform 3

Status: VALIDATED

Source sequence(s)

AC161805
NM_001421413.1 → NP_001408342.1 ras-related protein Rab-7L1 isoform 3

Status: VALIDATED

Source sequence(s)

AC161805
NM_001421414.1 → NP_001408343.1 ras-related protein Rab-7L1 isoform 1

Status: VALIDATED

Source sequence(s)

AC161805

UniProtKB/TrEMBL

E9QLQ7
NM_144875.3 → NP_659124.2 ras-related protein Rab-7L1 isoform 1

See identical proteins and their annotated locations for NP_659124.2

Status: VALIDATED

Source sequence(s)

AC161805

Consensus CDS

CCDS15276.1

UniProtKB/TrEMBL

E9QLQ7

Related

ENSMUSP00000027693.8, ENSMUST00000027693.8

Conserved Domains (2) summary

smart00175
Location:8 → 176

RAB; Rab subfamily of small GTPases

cd04107
Location:8 → 204

Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)