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    Ikbkb inhibitor of kappaB kinase beta [ Mus musculus (house mouse) ]

    Gene ID: 16150, updated on 28-Jan-2025

    Summary

    Official Symbol
    Ikbkbprovided by MGI
    Official Full Name
    inhibitor of kappaB kinase betaprovided by MGI
    Primary source
    MGI:MGI:1338071
    See related
    Ensembl:ENSMUSG00000031537 AllianceGenome:MGI:1338071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IKK2; IKK-2; IKK-B; IKK[b]; IKKbeta; NFKBIKB; IKK-beta
    Summary
    Enables IkappaB kinase activity and protein phosphatase binding activity. Involved in canonical NF-kappaB signal transduction; cell surface receptor signaling pathway; and peptidyl-serine phosphorylation. Acts upstream of or within B cell homeostasis; positive regulation of cation channel activity; and positive regulation of sodium ion transport. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex and IkappaB kinase complex. Is expressed in several structures, including cerebral cortex; genitourinary system; heart; and musculature. Used to study immunodeficiency 15A. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in spleen adult (RPKM 15.9), thymus adult (RPKM 12.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ikbkb in Genome Data Viewer
    Location:
    8 A2; 8 11.42 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23149228..23196605, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22659205..22706589, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930013F10 gene Neighboring gene dickkopf WNT signaling pathway inhibitor 4 Neighboring gene polymerase (DNA directed), beta Neighboring gene STARR-positive B cell enhancer ABC_E6626 Neighboring gene predicted gene 15346 Neighboring gene plasminogen activator, tissue Neighboring gene STARR-seq mESC enhancer starr_20910 Neighboring gene RIKEN cDNA 1700041G16 gene Neighboring gene STARR-seq mESC enhancer starr_20911 Neighboring gene STARR-positive B cell enhancer ABC_E188 Neighboring gene STARR-positive B cell enhancer ABC_E8844 Neighboring gene STARR-positive B cell enhancer ABC_E2859 Neighboring gene adaptor-related protein complex 3, mu 2 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 46
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    contributes_to IkappaB kinase activity  
    enables IkappaB kinase activity PubMed 
    enables IkappaB kinase activity PubMed 
    contributes_to IkappaB kinase activity  
    enables IkappaB kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding  
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase activity PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein kinase activity  
    enables protein kinase binding  
    enables protein phosphatase binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding  
    enables ribosomal protein S6 kinase activity  
    enables scaffold protein binding PubMed 
    enables transferrin receptor binding  
    Items 1 - 25 of 46
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell homeostasis PubMed 
    acts_upstream_of_or_within I-kappaB phosphorylation PubMed 
    involved_in canonical NF-kappaB signal transduction PubMed 
    involved_in canonical NF-kappaB signal transduction PubMed 
    involved_in canonical NF-kappaB signal transduction  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to tumor necrosis factor  
    involved_in chromatin remodeling  
    involved_in cortical actin cytoskeleton organization  
    involved_in integrin-mediated signaling pathway PubMed 
    involved_in interleukin-1-mediated signaling pathway  
    involved_in negative regulation of bicellular tight junction assembly  
    involved_in neuron projection development  
    involved_in peptidyl-serine phosphorylation PubMed 
    involved_in peptidyl-serine phosphorylation  
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    acts_upstream_of_or_within positive regulation of cation channel activity PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of neuron projection development  
    acts_upstream_of_or_within positive regulation of sodium ion transport PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein localization to plasma membrane  
    involved_in protein maturation  
    involved_in protein phosphorylation  
    involved_in regulation of establishment of endothelial barrier  
    involved_in regulation of phosphorylation  
    involved_in response to cholecystokinin  
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in tumor necrosis factor-mediated signaling pathway PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in tumor necrosis factor-mediated signaling pathway PubMed 
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    part_of CD40 receptor complex PubMed 
    part_of IkappaB kinase complex  
    part_of IkappaB kinase complex PubMed 
    part_of IkappaB kinase complex PubMed 
    part_of IkappaB kinase complex  
    is_active_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasmic side of plasma membrane PubMed 
    located_in cytosol  
    located_in membrane raft  
    located_in nucleus  

    General protein information

    Preferred Names
    inhibitor of nuclear factor kappa-B kinase subunit beta
    Names
    I-kappa-B kinase 2
    I-kappa-B-kinase beta
    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    nuclear factor NF-kappa-B inhibitor kinase beta
    serine/threonine protein kinase IKBKB
    NP_001153246.1
    NP_001411759.1
    NP_001411760.1
    NP_001411761.1
    NP_034676.1
    XP_006509085.1
    XP_036009657.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159774.2NP_001153246.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1

      See identical proteins and their annotated locations for NP_001153246.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC121835
      Consensus CDS
      CCDS52522.1
      UniProtKB/Swiss-Prot
      O88351, Q9R1J6
      UniProtKB/TrEMBL
      Q5D0E0
      Related
      ENSMUSP00000033939.7, ENSMUST00000033939.13
      Conserved Domains (3) summary
      smart00220
      Location:15290
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14038
      Location:20309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
      pfam12179
      Location:708742
      IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
    2. NM_001424830.1NP_001411759.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121835
      UniProtKB/Swiss-Prot
      O88351, Q9R1J6
    3. NM_001424831.1NP_001411760.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121835
      UniProtKB/TrEMBL
      Q05DR8
    4. NM_001424832.1NP_001411761.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC121835
    5. NM_010546.3NP_034676.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform 2

      See identical proteins and their annotated locations for NP_034676.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) retains sequence in the 3' coding region, which results in an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC121835
      Consensus CDS
      CCDS22182.1
      UniProtKB/Swiss-Prot
      O88351, Q9R1J6
      UniProtKB/TrEMBL
      A0A0R4J0T4
      Related
      ENSMUSP00000064235.4, ENSMUST00000063401.10
      Conserved Domains (2) summary
      smart00220
      Location:15290
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14038
      Location:20309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

    RNA

    1. NR_188955.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121835
    2. NR_188956.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121835
    3. NR_188957.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121835
      Related
      ENSMUST00000125314.8
    4. NR_188958.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121835
    5. NR_188959.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121835

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      23149228..23196605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153764.1XP_036009657.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4

      Conserved Domains (4) summary
      cd17046
      Location:31111
      Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
      pfam12179
      Location:429463
      IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
      pfam18397
      Location:110384
      IKBKB_SDD; IQBAL scaffold dimerization domain
      cl21453
      Location:130
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006509022.5XP_006509085.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3

      Related
      ENSMUSP00000138378.2, ENSMUST00000135326.8
      Conserved Domains (3) summary
      cd14038
      Location:20309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
      cd17046
      Location:310390
      Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins
      pfam18397
      Location:389528
      IKBKB_SDD; IQBAL scaffold dimerization domain
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