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    Mtmr10 myotubularin related protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 233315, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mtmr10provided by MGI
    Official Full Name
    myotubularin related protein 10provided by MGI
    Primary source
    MGI:MGI:2142292
    See related
    Ensembl:ENSMUSG00000030522 AllianceGenome:MGI:2142292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm and membrane. Is expressed in nose; ventricular layer; and vibrissa. Orthologous to human MTMR10 (myotubularin related protein 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.3), bladder adult (RPKM 6.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtmr10 in Genome Data Viewer
    Location:
    7 C; 7 34.63 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (63937443..63990556)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (64287670..64340806)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 1 Neighboring gene microRNA 211 Neighboring gene STARR-seq mESC enhancer starr_19035 Neighboring gene microRNA 6416 Neighboring gene STARR-seq mESC enhancer starr_19036 Neighboring gene STARR-seq mESC enhancer starr_19037 Neighboring gene STARR-seq mESC enhancer starr_19038 Neighboring gene STARR-seq mESC enhancer starr_19039 Neighboring gene FANCD2/FANCI-associated nuclease 1 Neighboring gene SET translocation pseudogene Neighboring gene M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:71537088-71537271

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out. Loupe JM, et al. Hum Mol Genet, 2020 Nov 4. PMID 32876667, Free PMC Article
    2. Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes. Stefan M, et al. BMC Genomics, 2005 Nov 9. PMID 16280085, Free PMC Article
    3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myotubularin-related protein 10
    Names
    inactive phosphatidylinositol 3-phosphatase 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420415.1 → NP_001407344.1  myotubularin-related protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139849

    2. NM_172742.3 → NP_766330.2  myotubularin-related protein 10 isoform 1

      See identical proteins and their annotated locations for NP_766330.2

      Status: VALIDATED

      Source sequence(s)
      AC139849
      Consensus CDS
      CCDS39976.1
      UniProtKB/Swiss-Prot
      Q6PE99, Q7TPM9
      Related
      ENSMUSP00000032736.5, ENSMUST00000032736.11
      Conserved Domains (3) summary
      cd13346
      Location:21 → 193
      PH-GRAM_MTMR10; Myotubularian (MTM) related 10 protein (MTMR10) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam12578
      Location:574 → 701
      3-PAP; Myotubularin-associated protein
      cl21483
      Location:222 → 503
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      63937443..63990556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPM9.2 GenPept UniProtKB/Swiss-Prot:Q7TPM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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