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    Efcab11 EF-hand calcium binding domain 11 [ Mus musculus (house mouse) ]

    Gene ID: 78767, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Efcab11provided by MGI
    Official Full Name
    EF-hand calcium binding domain 11provided by MGI
    Primary source
    MGI:MGI:1926017
    See related
    Ensembl:ENSMUSG00000021176 AllianceGenome:MGI:1926017
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610021K21Rik; 2610110A13Rik
    Summary
    Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cytoplasm. Is expressed in central nervous system; lung; and reproductive system. Orthologous to human EFCAB11 (EF-hand calcium binding domain 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 1.3), testis adult (RPKM 0.7) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Efcab11 in Genome Data Viewer
    Location:
    12 E; 12 50.25 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (99683790..99849701, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (99692195..99884442, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700064M15 gene Neighboring gene STARR-positive B cell enhancer mm9_chr12:100878651-100878951 Neighboring gene predicted gene, 53756 Neighboring gene predicted gene, 19951 Neighboring gene STARR-seq mESC enhancer starr_33027 Neighboring gene STARR-seq mESC enhancer starr_33028 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:101121576-101121877 Neighboring gene STARR-seq mESC enhancer starr_33029 Neighboring gene STARR-positive B cell enhancer mm9_chr12:101140770-101141071 Neighboring gene predicted gene, 57807 Neighboring gene tyrosyl-DNA phosphodiesterase 1 Neighboring gene STARR-seq mESC enhancer starr_33030 Neighboring gene potassium channel, subfamily K, member 13 Neighboring gene predicted gene, 51957

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand calcium-binding domain-containing protein 11
    Names
    EF-hand domain-containing protein C14orf143 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030172.2 → NP_084448.1  EF-hand calcium-binding domain-containing protein 11

      See identical proteins and their annotated locations for NP_084448.1

      Status: PROVISIONAL

      Source sequence(s)
      AC155266, AC160931
      Consensus CDS
      CCDS26104.1
      UniProtKB/Swiss-Prot
      Q9D041, Q9D0E5
      UniProtKB/TrEMBL
      A0A1Y7VKR2
      Related
      ENSMUSP00000044808.4, ENSMUST00000046485.5
      Conserved Domains (1) summary
      COG5126
      Location:14 → 152
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      99683790..99849701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0E5.1 GenPept UniProtKB/Swiss-Prot:Q9D0E5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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