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    Gabrr3 gamma-aminobutyric acid type A receptor subunit rho 3 [ Mus musculus (house mouse) ]

    Gene ID: 328699, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gabrr3provided by MGI
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit rho 3provided by MGI
    Primary source
    MGI:MGI:3588203
    See related
    Ensembl:ENSMUSG00000074991 AllianceGenome:MGI:3588203
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable GABA-A receptor activity and protein domain specific binding activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chloride transmembrane transport. Is active in GABA-ergic synapse and postsynaptic membrane. Is expressed in central nervous system and retina. Orthologous to human GABRR3 (gamma-aminobutyric acid type A receptor subunit rho3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Gabrr3 in Genome Data Viewer
    Location:
    16 C1.3; 16 34.83 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (59227745..59282102)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (59407382..59461739)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily AC member 25 Neighboring gene STARR-positive B cell enhancer mm9_chr16:59420656-59420957 Neighboring gene predicted gene, 33611 Neighboring gene RIKEN cDNA 1700022E09 gene Neighboring gene STARR-seq mESC enhancer starr_41108 Neighboring gene ORAI calcium release-activated calcium modulator 2, pseudogene Neighboring gene ribosomal oxygenase 2 Neighboring gene beta-gamma crystallin domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Huntington's disease leads to decrease of GABA-A tonic subunits in the D2 neostriatal pathway and their relocalization into the synaptic cleft. Rosas-Arellano A, et al. Neurobiol Dis, 2018 Feb. PMID 29196217
    2. GABAC receptors are functionally expressed in the intermediate zone and regulate radial migration in the embryonic mouse neocortex. Denter DG, et al. Neuroscience, 2010 Apr 28. PMID 20123002
    3. PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1. Rose M, et al. Mol Cell Neurosci, 2008 Apr. PMID 18325784
    4. Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord. Guo Z, et al. J Neurosci, 2012 Jun 20. PMID 22723691, Free PMC Article
    5. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit rho-3
    Names
    gamma-aminobutyric acid (GABA) receptor, rho 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081190.1 → NP_001074659.1  gamma-aminobutyric acid receptor subunit rho-3

      See identical proteins and their annotated locations for NP_001074659.1

      Status: PROVISIONAL

      Source sequence(s)
      AC154854
      Consensus CDS
      CCDS37371.1
      UniProtKB/TrEMBL
      B2RXA8
      Related
      ENSMUSP00000109980.3, ENSMUST00000114341.4
      Conserved Domains (3) summary
      TIGR00860
      Location:58 → 463
      LIC; Cation transporter family protein
      pfam02931
      Location:59 → 264
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:271 → 460
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      59227745..59282102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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