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    Dcn decorin [ Mus musculus (house mouse) ]

    Gene ID: 13179, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dcnprovided by MGI
    Official Full Name
    decorinprovided by MGI
    Primary source
    MGI:MGI:94872
    See related
    Ensembl:ENSMUSG00000019929 AllianceGenome:MGI:94872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DC; PG40; PGII; PGS2; DSPG2; SLRR1B
    Summary
    This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in bladder adult (RPKM 1095.0), subcutaneous fat pad adult (RPKM 305.9) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Dcn in Genome Data Viewer
    Location:
    10 C3; 10 50.27 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (97315362..97354025)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (97479500..97518163)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CWC15 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8867 Neighboring gene STARR-seq mESC enhancer starr_27689 Neighboring gene STARR-positive B cell enhancer ABC_E6912 Neighboring gene predicted gene, 34114 Neighboring gene microRNA 3966 Neighboring gene STARR-seq mESC enhancer starr_27690 Neighboring gene STARR-seq mESC enhancer starr_27691 Neighboring gene RIKEN cDNA 4930473O22 gene Neighboring gene lumican

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of collagen type VI trimer  
    located_in collagen-containing extracellular matrix PubMed 
    located_in extracellular matrix PubMed 
    located_in extracellular region  
    is_active_in extracellular space  

    General protein information

    Preferred Names
    decorin
    Names
    bone proteoglycan II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190451.2NP_001177380.1  decorin preproprotein

      See identical proteins and their annotated locations for NP_001177380.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC159710, AK145905, BG088078, BM114383
      Consensus CDS
      CCDS24141.1
      UniProtKB/Swiss-Prot
      P28654
      UniProtKB/TrEMBL
      Q3TSV1, Q3UKR1
      Related
      ENSMUSP00000100924.4, ENSMUST00000105287.11
      Conserved Domains (4) summary
      smart00013
      Location:4880
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:79285
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:5777
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:79136
      LRR_8; Leucine rich repeat
    2. NM_007833.6NP_031859.1  decorin preproprotein

      See identical proteins and their annotated locations for NP_031859.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA881173, AC159710, BB575065, BM114383, CK623125, DV056002, W62675
      Consensus CDS
      CCDS24141.1
      UniProtKB/Swiss-Prot
      P28654
      UniProtKB/TrEMBL
      Q3TSV1, Q3UKR1
      Related
      ENSMUSP00000131431.3, ENSMUST00000163448.4
      Conserved Domains (4) summary
      smart00013
      Location:4880
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:79285
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:5777
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:79136
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      97315362..97354025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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