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    Snx25 sorting nexin 25 [ Mus musculus (house mouse) ]

    Gene ID: 102141, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx25provided by MGI
    Official Full Name
    sorting nexin 25provided by MGI
    Primary source
    MGI:MGI:2142610
    See related
    Ensembl:ENSMUSG00000038291 AllianceGenome:MGI:2142610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm173; Gm1699; Sbbi31
    Summary
    Enables type I transforming growth factor beta receptor binding activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway and receptor catabolic process. Located in endosome. Orthologous to human SNX25 (sorting nexin 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.5), lung adult (RPKM 7.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snx25 in Genome Data Viewer
    Location:
    8 B1.1; 8 26.03 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (46486298..46605535, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (46033261..46152441, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene UFM1-specific peptidase 2 Neighboring gene STARR-positive B cell enhancer ABC_E10496 Neighboring gene ankyrin repeat domain 37 Neighboring gene Lrp2 binding protein Neighboring gene STARR-seq mESC enhancer starr_21377 Neighboring gene STARR-positive B cell enhancer ABC_E10497 Neighboring gene predicted gene 15634 Neighboring gene cilia and flagella associated protein 97 Neighboring gene STARR-positive B cell enhancer ABC_E10498 Neighboring gene solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Redox-modulated SNX25 as a novel regulator of GPCR-G protein signaling from endosomes. Zhang Y, et al. Redox Biol, 2024 Sep. PMID 38936254, Free PMC Article
    2. Circadian rhythms of sorting nexin 25 in the mouse suprachiasmatic nucleus. Takemura S, et al. Neurosci Lett, 2020 May 14. PMID 32156614
    3. Neural expression of sorting nexin 25 and its regulation of tyrosine receptor kinase B trafficking. Takemura S, et al. Brain Struct Funct, 2020 Dec. PMID 32955616
    4. Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25-Nrf2 pathway. Tanaka T, et al. Nat Immunol, 2023 Mar. PMID 36703006, Free PMC Article
    5. SNX25 regulates TGF-β signaling by enhancing the receptor degradation. Hao X, et al. Cell Signal, 2011 May. PMID 21266196

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Redox-modulated SNX25 as a novel regulator of GPCR-G protein signaling from endosomes.
      Title: Redox-modulated SNX25 as a novel regulator of GPCR-G protein signaling from endosomes.
    2. Neural expression of sorting nexin 25 and its regulation of tyrosine receptor kinase B trafficking.
      Title: Neural expression of sorting nexin 25 and its regulation of tyrosine receptor kinase B trafficking.
    3. Circadian rhythms of sorting nexin 25 in the mouse suprachiasmatic nucleus.
      Title: Circadian rhythms of sorting nexin 25 in the mouse suprachiasmatic nucleus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables type I transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372342.1 → NP_001359271.1  sorting nexin-25 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114558
      Consensus CDS
      CCDS90394.1
      UniProtKB/TrEMBL
      E9Q1K0
      Related
      ENSMUSP00000106007.3, ENSMUST00000110378.9
      Conserved Domains (5) summary
      cd06878
      Location:648 → 770
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      pfam02194
      Location:148 → 303
      PXA; PXA domain
      pfam08628
      Location:847 → 950
      Nexin_C; Sorting nexin C terminal
      pfam12761
      Location:558 → 645
      End3; Actin cytoskeleton-regulatory complex protein END3
      cl02565
      Location:437 → 545
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. NM_001372343.1 → NP_001359272.1  sorting nexin-25 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114558
      Conserved Domains (5) summary
      cd06878
      Location:648 → 770
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      pfam02194
      Location:148 → 303
      PXA; PXA domain
      pfam08628
      Location:845 → 948
      Nexin_C; Sorting nexin C terminal
      pfam12761
      Location:558 → 645
      End3; Actin cytoskeleton-regulatory complex protein END3
      cl02565
      Location:437 → 545
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. NM_207213.3 → NP_997096.2  sorting nexin-25 isoform 3

      See identical proteins and their annotated locations for NP_997096.2

      Status: VALIDATED

      Source sequence(s)
      AC114558
      Consensus CDS
      CCDS22287.2
      UniProtKB/Swiss-Prot
      E9QMG5, Q3ZT31, Q6PGF1
      Related
      ENSMUSP00000035785.9, ENSMUST00000041582.15
      Conserved Domains (4) summary
      cd06878
      Location:502 → 624
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      pfam02194
      Location:2 → 157
      PXA; PXA domain
      pfam08628
      Location:701 → 804
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:291 → 399
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      46486298..46605535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153706.1 → XP_036009599.1  sorting nexin-25 isoform X1

      UniProtKB/TrEMBL
      Q7TQF4
      Conserved Domains (3) summary
      cd06878
      Location:348 → 470
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      pfam08628
      Location:547 → 650
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:137 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RNA

    1. XR_004934742.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZT31.3 GenPept UniProtKB/Swiss-Prot:Q3ZT31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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