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    Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 [ Mus musculus (house mouse) ]

    Gene ID: 394434, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ugt1a9provided by MGI
    Official Full Name
    UDP glucuronosyltransferase 1 family, polypeptide A9provided by MGI
    Primary source
    MGI:MGI:3576092
    See related
    Ensembl:ENSMUSG00000090175 AllianceGenome:MGI:3576092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UDPGT; UGTP4; UGT1.9; UGT1-09; Ugt1a12; mUGTBr/P; UDPGT 1-9
    Summary
    Predicted to enable several functions, including monocarboxylic acid binding activity; protein dimerization activity; and protein kinase C binding activity. Predicted to be involved in cellular glucuronidation and liver development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in alcoholic pancreatitis and pancreatic cancer. Orthologous to several human genes including UGT1A10 (UDP glucuronosyltransferase family 1 member A10); UGT1A7 (UDP glucuronosyltransferase family 1 member A7); and UGT1A8 (UDP glucuronosyltransferase family 1 member A8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 233.5), liver adult (RPKM 172.5) and 9 other tissues See more
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    Genomic context

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    See Ugt1a9 in Genome Data Viewer
    Location:
    1 D; 1 44.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87998501..88147724)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88070779..88220002)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 pseudogene Neighboring gene predicted gene, 38421 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 Neighboring gene STARR-seq mESC enhancer starr_01626 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6B Neighboring gene STARR-seq mESC enhancer starr_01627 Neighboring gene STARR-seq mESC enhancer starr_01628 Neighboring gene predicted gene 15372 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6A Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 pseudogene Neighboring gene predicted gene 15371 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene predicted gene 15368 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90112870-90113171 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90113610-90113910 Neighboring gene predicted gene 15376 Neighboring gene STARR-seq mESC enhancer starr_01629 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90118277-90118578 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene STARR-positive B cell enhancer mm9_chr1:90185502-90185802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90186563-90186863 Neighboring gene Holliday junction recognition protein Neighboring gene STARR-positive B cell enhancer mm9_chr1:90195708-90196009 Neighboring gene transient receptor potential cation channel, subfamily M, member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus. Shi R, et al. Biopharm Drug Dispos, 2016 Oct. PMID 27514509
    2. Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice. Xu H, et al. Drug Metab Dispos, 2020 Aug. PMID 32527940
    3. Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p). Kong AN, et al. Pharm Res, 1993 Mar. PMID 8464825
    4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
    5. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circadian Clock Component Rev-erbalpha Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.
      Title: Circadian Clock Component Rev-erbα Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice.
    2. Diabetes mellitus caused a decrease in the activity of Cyp3a11-mediated testosterone-6beta-hydroxylation, but no change in the activity of Cyp3a11-mediated midazolam 1-hydroxylation and an increase in the activity of UGT1a9-mediated propofol O-glucuronidation in db/db mice
      Title: Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in liver development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronosyltransferase 1A9
    Names
    UDP glycosyltransferase 1 family polypeptide A12
    UDP-glucuronosyltransferase 1-7
    UDP-glucuronosyltransferase 1-9
    NP_964006.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201644.2 → NP_964006.2  UDP-glucuronosyltransferase 1A9 precursor

      See identical proteins and their annotated locations for NP_964006.2

      Status: VALIDATED

      Source sequence(s)
      AC087780, AC087801, AY227200
      Consensus CDS
      CCDS15138.1
      UniProtKB/Swiss-Prot
      A6H6W3, E9QN27, Q62452, Q6XL44
      UniProtKB/TrEMBL
      Q5FW80
      Related
      ENSMUSP00000073444.5, ENSMUST00000073772.5
      Conserved Domains (2) summary
      PHA03392
      Location:9 → 500
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:24 → 519
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      87998501..88147724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62452.3 GenPept UniProtKB/Swiss-Prot:Q62452

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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