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    Bmx BMX non-receptor tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 12169, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bmxprovided by MGI
    Official Full Name
    BMX non-receptor tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:1101778
    See related
    Ensembl:ENSMUSG00000031377 AllianceGenome:MGI:1101778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Etk; Tyro8; Etk/Bmx
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in B cell receptor signaling pathway; adaptive immune response; and protein autophosphorylation. Predicted to be located in nucleoplasm and ruffle membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; hemolymphoid system; and mammary gland. Orthologous to human BMX (BMX non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 1.1), lung adult (RPKM 0.9) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Bmx in Genome Data Viewer
    Location:
    X F5; X 76.12 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (162975838..163041189, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164192842..164258193, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene collectrin, amino acid transport regulator Neighboring gene STARR-seq mESC enhancer starr_48236 Neighboring gene angiotensin converting enzyme 2 Neighboring gene predicted gene, 19251 Neighboring gene STARR-seq mESC enhancer starr_48237 Neighboring gene predicted gene, 46692 Neighboring gene predicted gene, 57673 Neighboring gene pirin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables metal ion binding  
    enables non-membrane spanning protein tyrosine kinase activity  
    enables non-membrane spanning protein tyrosine kinase activity  
    enables non-membrane spanning protein tyrosine kinase activity  
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway  
    involved_in adaptive immune response  
    involved_in apoptotic process  
    involved_in cell adhesion  
    involved_in chromatin remodeling  
    involved_in intracellular signal transduction  
    involved_in protein autophosphorylation  
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in nucleoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in ruffle membrane  

    General protein information

    Preferred Names
    cytoplasmic tyrosine-protein kinase BMX
    Names
    TYRO8 protein tyrosine kinase 8
    bone marrow tyrosine kinase gene in chromosome X protein homolog
    NP_033889.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009759.4NP_033889.2  cytoplasmic tyrosine-protein kinase BMX

      Status: VALIDATED

      Source sequence(s)
      AK036707, AK040936
      Consensus CDS
      CCDS30519.2
      UniProtKB/Swiss-Prot
      P97504
      UniProtKB/TrEMBL
      B1AUL5, B1AUL6
      Related
      ENSMUSP00000107884.3, ENSMUST00000112265.9
      Conserved Domains (5) summary
      cd10399
      Location:269374
      SH2_Tec_Bmx; Src homology 2 (SH2) domain found in Tec protein, Bmx
      cd01238
      Location:25151
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      pfam00169
      Location:27115
      PH; PH domain
      pfam07714
      Location:397646
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:392647
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      162975838..163041189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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