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    Hrh4 histamine receptor H4 [ Mus musculus (house mouse) ]

    Gene ID: 225192, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hrh4provided by MGI
    Official Full Name
    histamine receptor H4provided by MGI
    Primary source
    MGI:MGI:2429635
    See related
    Ensembl:ENSMUSG00000037346 AllianceGenome:MGI:2429635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H4; H4R; BG26; HH4R; AXOR35; GPRv53; GPCR105
    Summary
    Enables histamine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; and chemical synaptic transmission. Predicted to act upstream of or within inflammatory response. Located in membrane. Orthologous to human HRH4 (histamine receptor H4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 1.0) and spleen adult (RPKM 0.1) See more
    Orthologs
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    Genomic context

    See Hrh4 in Genome Data Viewer
    Location:
    18 A1; 18 6.88 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (13140039..13156758)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (13006982..13023701)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 1A Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9448 Neighboring gene impact, RWD domain protein Neighboring gene ribosomal protein SA pseudogene Neighboring gene predicted gene, 36563

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC130500

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histamine receptor activity  
    enables histamine receptor activity PubMed 
    enables histamine receptor activity  
    enables neurotransmitter receptor activity  
    Component Evidence Code Pubs
    is_active_in dendrite  
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    is_active_in synapse  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153087.2NP_694727.1  histamine H4 receptor

      See identical proteins and their annotated locations for NP_694727.1

      Status: VALIDATED

      Source sequence(s)
      AC131672
      Consensus CDS
      CCDS29069.1
      UniProtKB/Swiss-Prot
      Q91ZY2
      Related
      ENSMUSP00000041061.3, ENSMUST00000041676.3
      Conserved Domains (1) summary
      pfam00001
      Location:32360
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      13140039..13156758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317874.1XP_017173363.1  histamine H4 receptor isoform X2

      UniProtKB/TrEMBL
      B2ZGH2
      Related
      ENSMUSP00000157130.2, ENSMUST00000234565.2
      Conserved Domains (2) summary
      cd14964
      Location:1842
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:16129
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_006525817.2XP_006525880.1  histamine H4 receptor isoform X1

      See identical proteins and their annotated locations for XP_006525880.1

      UniProtKB/TrEMBL
      Q2M2N7
      Conserved Domains (2) summary
      cd14964
      Location:521
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1247
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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