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    Fscn2 fascin actin-bundling protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 238021, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fscn2provided by MGI
    Official Full Name
    fascin actin-bundling protein 2provided by MGI
    Primary source
    MGI:MGI:2443337
    See related
    Ensembl:ENSMUSG00000025380 AllianceGenome:MGI:2443337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ahl8; A930022G03; C630046B20Rik
    Summary
    Predicted to enable actin filament binding activity. Acts upstream of or within eye photoreceptor cell development. Located in actin cytoskeleton and stereocilium. Is expressed in retina. Used to study auditory system disease; retinal degeneration; and retinitis pigmentosa 30. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 30. Orthologous to human FSCN2 (fascin actin-bundling protein 2, retinal). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Fscn2 in Genome Data Viewer
    Location:
    11 E2; 11 84.08 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120250991..120258999)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120360165..120368173)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 0610009L18 gene Neighboring gene microRNA 6935 Neighboring gene actin, gamma, cytoplasmic 1 Neighboring gene Fanconi anemia core complex associated protein 100 Neighboring gene NPL4 homolog, ubiquitin recognition factor Neighboring gene STARR-seq mESC enhancer starr_31358 Neighboring gene STARR-seq mESC enhancer starr_31359

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Clone Names

    • MGC130378, MGC130379

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding  
    enables actin filament binding  
    enables actin filament binding  
    enables protein-macromolecule adaptor activity  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization  
    involved_in actin filament bundle assembly  
    involved_in actin filament organization  
    involved_in cell migration  
    involved_in establishment or maintenance of cell polarity  
    acts_upstream_of_or_within eye photoreceptor cell development PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton  
    located_in actin cytoskeleton PubMed 
    is_active_in cytoplasm  
    located_in cytosol  
    located_in stereocilium PubMed 

    General protein information

    Preferred Names
    fascin-2
    Names
    fascin homolog 2, actin-bundling protein, retinal
    retinal fascin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172802.4NP_766390.2  fascin-2

      See identical proteins and their annotated locations for NP_766390.2

      Status: VALIDATED

      Source sequence(s)
      AK050002, BB279997, BC109356
      Consensus CDS
      CCDS25731.1
      UniProtKB/Swiss-Prot
      Q32M02, Q8BWU0
      Related
      ENSMUSP00000026445.3, ENSMUST00000026445.3
      Conserved Domains (2) summary
      cd00257
      Location:381492
      Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
      pfam06268
      Location:266376
      Fascin; Fascin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120250991..120258999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533259.4XP_006533322.1  fascin-2 isoform X1

      Conserved Domains (2) summary
      cd00257
      Location:408519
      Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
      pfam06268
      Location:266373
      Fascin; Fascin domain
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