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    Sf3a2 splicing factor 3a, subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 20222, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sf3a2provided by MGI
    Official Full Name
    splicing factor 3a, subunit 2provided by MGI
    Primary source
    MGI:MGI:104912
    See related
    Ensembl:ENSMUSG00000020211 AllianceGenome:MGI:104912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    66kDa; PRP11; SFA66; Sap62
    Summary
    Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in U2-type prespliceosome assembly and positive regulation of neuron projection development. Predicted to act upstream of or within RNA splicing, via transesterification reactions. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP and spliceosomal complex. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human SF3A2 (splicing factor 3a subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 42.2), ovary adult (RPKM 32.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Sf3a2 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80634569..80640756)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80798735..80804922)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DOT1 like histone lysine methyltransferase Neighboring gene STARR-seq mESC enhancer starr_27297 Neighboring gene VISTA enhancer mm200 Neighboring gene pleckstrin homology domain containing, family J member 1 Neighboring gene Amh promoter region Neighboring gene anti-Mullerian hormone Neighboring gene junctional sarcoplasmic reticulum protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding  
    enables protein binding PubMed 
    enables zinc ion binding  
    Component Evidence Code Pubs
    part_of U2 snRNP  
    part_of U2 snRNP  
    part_of U2 snRNP  
    part_of U2-type precatalytic spliceosome  
    part_of U2-type precatalytic spliceosome  
    part_of U2-type prespliceosome  
    part_of U2-type spliceosomal complex  
    part_of catalytic step 2 spliceosome  
    part_of catalytic step 2 spliceosome  
    located_in nuclear speck  
    located_in nucleus  
    located_in nucleus PubMed 
    part_of spliceosomal complex  

    General protein information

    Preferred Names
    splicing factor 3A subunit 2
    Names
    SAP 62
    SF3a66
    spliceosomal protein gene 62
    spliceosome-associated protein 62
    splicing factor 3a, subunit 2, 66kD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013651.4NP_038679.3  splicing factor 3A subunit 2

      See identical proteins and their annotated locations for NP_038679.3

      Status: VALIDATED

      Source sequence(s)
      BC052697, CX212776, CX214888
      Consensus CDS
      CCDS35986.2
      UniProtKB/TrEMBL
      G3UVU2
      Related
      ENSMUSP00000117160.2, ENSMUST00000148665.8
      Conserved Domains (2) summary
      COG5246
      Location:1217
      PRP11; Splicing factor 3a, subunit 2 [RNA processing and modification]
      cl26386
      Location:324449
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80634569..80640756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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