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    Pcdhb2 protocadherin beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 93873, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pcdhb2provided by MGI
    Official Full Name
    protocadherin beta 2provided by MGI
    Primary source
    MGI:MGI:2136735
    See related
    Ensembl:ENSMUSG00000051599 AllianceGenome:MGI:2136735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PcdhbB
    Summary
    Predicted to be involved in cell adhesion. Predicted to be active in plasma membrane. Is expressed in cerebral cortex. Orthologous to human PCDHB2 (protocadherin beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Pcdhb2 in Genome Data Viewer
    Location:
    18 B3; 18 19.46 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37427893..37430667)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37294840..37297614)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 1 Neighboring gene protocadherin alpha 2 Neighboring gene protocadherin alpha 4B Neighboring gene protocadherin alpha 3 Neighboring gene protocadherin alpha 4 Neighboring gene predicted gene, 38666 Neighboring gene protocadherin alpha 5 Neighboring gene predicted gene, 38667 Neighboring gene protocadherin alpha 6 Neighboring gene protocadherin alpha 7 Neighboring gene protocadherin alpha 8 Neighboring gene protocadherin alpha 10 Neighboring gene protocadherin alpha 9 Neighboring gene protocadherin alpha 11 Neighboring gene protocadherin alpha 12 Neighboring gene protocadherin alpha subfamily C, 1 Neighboring gene protocadherin alpha subfamily C, 2 Neighboring gene predicted gene 10544 Neighboring gene STARR-seq mESC enhancer starr_44309 Neighboring gene protocadherin beta 1 Neighboring gene RAD18 homolog pseudogene Neighboring gene protocadherin beta 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting. Hasegawa S, et al. Front Mol Neurosci, 2016. PMID 28066179, Free PMC Article
    2. Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice. Xu L, et al. Sci Adv, 2021 Jan. PMID 33523829, Free PMC Article
    3. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. Vanhalst K, et al. FEBS Lett, 2001 Apr 20. PMID 11322959
    4. CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. Elbert A, et al. J Neurosci, 2019 Jan 2. PMID 30377227, Free PMC Article
    5. Clustered gamma-protocadherins regulate cortical interneuron programmed cell death. Mancia Leon WR, et al. Elife, 2020 Jul 7. PMID 32633719, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protocadherin beta-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053127.2 → NP_444357.1  protocadherin beta-2

      See identical proteins and their annotated locations for NP_444357.1

      Status: VALIDATED

      Source sequence(s)
      AY013781, BB617745, BC021789
      Consensus CDS
      CCDS29170.1
      UniProtKB/TrEMBL
      B2RUH7, Q91Y00
      Related
      ENSMUSP00000057921.4, ENSMUST00000056522.5
      Conserved Domains (3) summary
      cd11304
      Location:457 → 559
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:33 → 114
      Cadherin_2; Cadherin-like
      pfam16492
      Location:689 → 771
      Cadherin_C_2; Cadherin cytoplasmic C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      37427893..37430667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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