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    Pira1 paired-Ig-like receptor A1 [ Mus musculus (house mouse) ]

    Gene ID: 18722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pira1provided by MGI
    Official Full Name
    paired-Ig-like receptor A1provided by MGI
    Primary source
    MGI:MGI:1195971
    See related
    Ensembl:ENSMUSG00000081665 AllianceGenome:MGI:1195971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pir; 6M21; Ly89; PIR-A1; Gm15922
    Summary
    Predicted to be involved in negative regulation of osteoclast differentiation. Orthologous to human LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 12.1), mammary gland adult (RPKM 5.4) and 13 other tissues See more
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    Genomic context

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    See Pira1 in Genome Data Viewer
    Location:
    7 A1; 7 2.15 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3734625..3742957, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3731626..3739943, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2812 Neighboring gene ribosomal protein S9 Neighboring gene STARR-positive B cell enhancer mm9_chr7:3672088-3672388 Neighboring gene paired Ig-like receptor B Neighboring gene paired-Ig-like receptor A2, pseudogene 2 Neighboring gene paired-Ig-like receptor A2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Paired immunoglobulin-like receptors and their MHC class I recognition. Takai T. Immunology, 2005 Aug. PMID 16011512, Free PMC Article
    2. PIR-B-deficient mice are susceptible to Salmonella infection. Torii I, et al. J Immunol, 2008 Sep 15. PMID 18768880, Free PMC Article
    3. Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development. Ben Baruch-Morgenstern N, et al. Nat Immunol, 2014 Jan. PMID 24212998, Free PMC Article
    4. Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. Licciulli S, et al. Leukemia, 2010 Feb. PMID 20010624
    5. A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex. Kasahara M, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370446, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate a critical role for PIR-B and PIR-A in eosinophil development.
      Title: Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development.
    2. Disruption of paired immunoglobulin-like activating (PIR-A) and inhibitory (PIR-B) receptor isoform balance affects their regulatory roles in host defense during Salmonella infection.
      Title: PIR-B-deficient mice are susceptible to Salmonella infection.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    paired-Ig-like receptor A1
    Names
    paired immunoglobulin-like receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371068.1 → NP_001357997.1  paired-Ig-like receptor A1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC171680
      UniProtKB/TrEMBL
      A2NTK2
      Conserved Domains (1) summary
      cl11960
      Location:123 → 219
      Ig; Immunoglobulin domain

    RNA

    1. NR_163846.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171680
      Related
      ENSMUST00000118068.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      3734625..3742957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152778.1 → XP_036008671.1  paired-Ig-like receptor A1 isoform X1

      UniProtKB/TrEMBL
      A2NTK2
      Conserved Domains (2) summary
      cd00096
      Location:130 → 134
      Ig; Ig strand A [structural motif]
      cl11960
      Location:129 → 225
      Ig; Immunoglobulin domain

    2. XM_017322037.3 → XP_017177526.1  paired-Ig-like receptor A1 isoform X2

      UniProtKB/TrEMBL
      A2NTK2
      Conserved Domains (1) summary
      cl11960
      Location:28 → 124
      Ig; Immunoglobulin domain

    3. XM_036152779.1 → XP_036008672.1  paired-Ig-like receptor A1 isoform X3

      UniProtKB/TrEMBL
      A2NTK2
      Conserved Domains (2) summary
      cd00096
      Location:35 → 39
      Ig; Ig strand A [structural motif]
      cl11960
      Location:34 → 123
      Ig; Immunoglobulin domain

    4. XM_036152780.1 → XP_036008673.1  paired-Ig-like receptor A1 isoform X4

      Conserved Domains (2) summary
      cd00096
      Location:130 → 134
      Ig; Ig strand A [structural motif]
      cl11960
      Location:129 → 225
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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