U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Epsti1 epithelial stromal interaction 1 [ Mus musculus (house mouse) ]

    Gene ID: 108670, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Epsti1provided by MGI
    Official Full Name
    epithelial stromal interaction 1provided by MGI
    Primary source
    MGI:MGI:1915168
    See related
    Ensembl:ENSMUSG00000022014 AllianceGenome:MGI:1915168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BRESI1; 2310046K10Rik; 5033415K03Rik
    Summary
    Acts upstream of or within several processes, including cellular response to lipopolysaccharide; cellular response to type II interferon; and macrophage differentiation. Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human EPSTI1 (epithelial stromal interaction 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 10.2), thymus adult (RPKM 9.5) and 13 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Epsti1 in Genome Data Viewer
    Location:
    14 D3; 14 41.08 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (78141679..78240096)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (77904239..78002656)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1587 Neighboring gene DnaJ heat shock protein family (Hsp40) member C15 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:78261113-78261296 Neighboring gene STARR-seq mESC enhancer starr_37217 Neighboring gene STARR-seq mESC enhancer starr_37218 Neighboring gene family with sequence similarity 216, member B Neighboring gene predicted gene, 30608

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Regulation of inflammatory gene expression in macrophages by epithelial-stromal interaction 1 (Epsti1). Kim YH, et al. Biochem Biophys Res Commun, 2018 Feb 5. PMID 29217193
    2. EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression. Bei YR, et al. Acta Pharmacol Sin, 2023 Jan. PMID 35778487, Free PMC Article
    3. Integrating genetic and network analysis to characterize genes related to mouse weight. Ghazalpour A, et al. PLoS Genet, 2006 Aug 18. PMID 16934000, Free PMC Article
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    epithelial-stromal interaction protein 1
    Names
    epithelial stromal interaction 1 (breast)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029495.2 → NP_083771.1  epithelial-stromal interaction protein 1 isoform a

      See identical proteins and their annotated locations for NP_083771.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK077223, AK135710, BY719992
      Consensus CDS
      CCDS56971.1
      UniProtKB/Swiss-Prot
      Q80WK5, Q8VDI1, Q8VDW6
      UniProtKB/TrEMBL
      A0A140T8I6
      Related
      ENSMUSP00000022591.9, ENSMUST00000022591.16
      Conserved Domains (1) summary
      pfam04687
      Location:13 → 197
      Microvir_H; Microvirus H protein (pilot protein)

    2. NM_178825.4 → NP_849147.1  epithelial-stromal interaction protein 1 isoform b

      See identical proteins and their annotated locations for NP_849147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) uses an alternate 3' coding region and 3' UTR, compared to variant a. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AI592213, AK017174, BE628578, BY719992
      Consensus CDS
      CCDS88718.1
      UniProtKB/TrEMBL
      Q9D3Q7
      Related
      ENSMUSP00000154502.2, ENSMUST00000227903.2
      Conserved Domains (1) summary
      pfam04687
      Location:13 → 197
      Microvir_H; Microvirus H protein (pilot protein)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      78141679..78240096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDI1.2 GenPept UniProtKB/Swiss-Prot:Q8VDI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous