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    Ndufaf3 NADH:ubiquinone oxidoreductase complex assembly factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 66706, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndufaf3provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase complex assembly factor 3provided by MGI
    Primary source
    MGI:MGI:1913956
    See related
    Ensembl:ENSMUSG00000070283 AllianceGenome:MGI:1913956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4733401H18Rik
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 18. Orthologous to human NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 180.2), adrenal adult (RPKM 40.7) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Ndufaf3 in Genome Data Viewer
    Location:
    9 F2; 9 59.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108442786..108444635, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108565587..108567436, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene glutamine-rich 1 Neighboring gene STARR-positive B cell enhancer ABC_E3861 Neighboring gene inosine monophosphate dehydrogenase 2 Neighboring gene STARR-positive B cell enhancer ABC_E3862 Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene microRNA 191 Neighboring gene microRNA 425

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrion PubMed 
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
    Names
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
    nuclear protein E3-3
    protein 2P1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023247.2NP_075736.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

      See identical proteins and their annotated locations for NP_075736.1

      Status: VALIDATED

      Source sequence(s)
      AF235017, AI837285, CT010508
      Consensus CDS
      CCDS23531.1
      UniProtKB/Swiss-Prot
      Q8K1A3, Q9JKL4
      Related
      ENSMUSP00000073832.5, ENSMUST00000074208.6
      Conserved Domains (1) summary
      cd05125
      Location:59172
      Mth938_2P1-like; Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108442786..108444635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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