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    Gprc5a G protein-coupled receptor, family C, group 5, member A [ Mus musculus (house mouse) ]

    Gene ID: 232431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gprc5aprovided by MGI
    Official Full Name
    G protein-coupled receptor, family C, group 5, member Aprovided by MGI
    Primary source
    MGI:MGI:1891250
    See related
    Ensembl:ENSMUSG00000046733 AllianceGenome:MGI:1891250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rai3; Raig1
    Summary
    Predicted to enable protein kinase activator activity. Involved in negative regulation of epidermal growth factor-activated receptor activity. Located in plasma membrane. Is expressed in several structures, including gut; nose; respiratory system; submandibular gland primordium; and urinary system. Orthologous to human GPRC5A (G protein-coupled receptor class C group 5 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 130.8), colon adult (RPKM 45.8) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gprc5a in Genome Data Viewer
    Location:
    6 G1; 6 65.83 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135042660..135061707)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135065662..135084709)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36428 Neighboring gene apolipoprotein L domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E865 Neighboring gene DEAD box helicase 47 Neighboring gene STARR-seq mESC enhancer starr_17562 Neighboring gene G protein-coupled receptor, family C, group 5, member D Neighboring gene Hebp1R1 erythroid cis-regulatory module Neighboring gene fucose mutarotase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knockout of the tumor suppressor gene Gprc5a in mice leads to NF-kappaB activation in airway epithelium and promotes lung inflammation and tumorigenesis. Deng J, et al. Cancer Prev Res (Phila), 2010 Apr. PMID 20354164, Free PMC Article
    2. Identification of Active Bronchioalveolar Stem Cells as the Cell of Origin in Lung Adenocarcinoma. Yin H, et al. Cancer Res, 2022 Mar 15. PMID 35045987
    3. Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice. Fujimoto J, et al. PLoS One, 2010 Jul 29. PMID 20686609, Free PMC Article
    4. Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor. Chen Y, et al. Cancer Res, 2010 Nov 1. PMID 20959490, Free PMC Article
    5. Gprc5a-deficiency confers susceptibility to endotoxin-induced acute lung injury via NF-κB pathway. Liao Y, et al. Cell Cycle, 2015. PMID 25714996, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation.
      Title: Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation.
    2. Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker.
      Title: Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker.
    3. microRNA-367-3p regulation of GPRC5A is suppressed in ischemic stroke.
      Title: microRNA-367-3p regulation of GPRC5A is suppressed in ischemic stroke.
    4. PTGES/PGE2 signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model.
      Title: PTGES/PGE(2) signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model.
    5. Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
      Title: Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
    6. GPRC5A reduction contributes to pollutant benzo[a]pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients.
      Title: GPRC5A reduction contributes to pollutant benzo[a]pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients.
    7. On the basis of our findings in human DN and in Gprc5a deficient mice, we believe that chronic reduction in Gprc5a expression plays a pathogenic role in the progression of DN. Results in cell culture support our other findings in mice showing that Gprc5a modulates EGFR and TGF-b signaling in podocytes.
      Title: Depletion of Gprc5a Promotes Development of Diabetic Nephropathy.
    8. G protein-coupled receptor family C group 5 member A (GPRC5A) deficiency contributes to dysregulated proto-oncogene protein c-mdm2 (MDM2) via activated epidermal growth factor receptor (EGFR) signaling, which promotes lung tumor development.
      Title: GPRC5A deficiency leads to dysregulated MDM2 via activated EGFR signaling for lung tumor development.
    9. GPRC5a was upregulated in pancreatic cancer (PaCa) leading to an enhanced drug resistance in PaCa cells.
      Title: The Effect of GPRC5a on the Proliferation, Migration Ability, Chemotherapy Resistance, and Phosphorylation of GSK-3β in Pancreatic Cancer.
    10. under-expressed GPRC5A during lung tumorigenesis enhances any transcriptional stimulation through an active translational status.
      Title: GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epidermal growth factor-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular exosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    retinoic acid-induced protein 3
    Names
    RAIG-1
    retinoic acid induced 3
    retinoic acid-induced gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181444.5 → NP_852109.2  retinoic acid-induced protein 3

      See identical proteins and their annotated locations for NP_852109.2

      Status: VALIDATED

      Source sequence(s)
      AC131718
      Consensus CDS
      CCDS20644.1
      UniProtKB/Swiss-Prot
      Q8BHL4, Q8K067, Q8K1G5
      UniProtKB/TrEMBL
      G5E8C3
      Related
      ENSMUSP00000061062.8, ENSMUST00000050104.8
      Conserved Domains (1) summary
      cd15279
      Location:28 → 272
      7tmC_RAIG1_4_GPRC5A_D; retinoic acid-inducible orphan G-protein-coupled receptors 1 and 4; class C family of seven-transmembrane G protein-coupled receptors, group 5, member A and D

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      135042660..135061707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506038.3 → XP_006506101.1  retinoic acid-induced protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006506101.1

      UniProtKB/Swiss-Prot
      Q8BHL4, Q8K067, Q8K1G5
      UniProtKB/TrEMBL
      G5E8C3
      Conserved Domains (1) summary
      cd15279
      Location:28 → 272
      7tmC_RAIG1_4_GPRC5A_D; retinoic acid-inducible orphan G-protein-coupled receptors 1 and 4; class C family of seven-transmembrane G protein-coupled receptors, group 5, member A and D
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHL4.1 GenPept UniProtKB/Swiss-Prot:Q8BHL4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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