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    Fam83b family with sequence similarity 83, member B [ Mus musculus (house mouse) ]

    Gene ID: 208994, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fam83bprovided by MGI
    Official Full Name
    family with sequence similarity 83, member Bprovided by MGI
    Primary source
    MGI:MGI:2685362
    See related
    Ensembl:ENSMUSG00000032358 AllianceGenome:MGI:2685362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm516; C530008M07Rik
    Summary
    Predicted to enable epidermal growth factor receptor binding activity; phosphatidylinositol 3-kinase binding activity; and protein kinase binding activity. Predicted to be involved in cell population proliferation; positive regulation of epidermal growth factor receptor signaling pathway; and signal transduction. Predicted to be active in cytoplasm and membrane. Is expressed in midgut; skin; stomach; and vibrissa. Orthologous to human FAM83B (family with sequence similarity 83 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 1.4), small intestine adult (RPKM 1.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam83b in Genome Data Viewer
    Location:
    9 D; 9 42.67 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (76394742..76474397, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (76487460..76567115, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene GDNF family receptor alpha like Neighboring gene STARR-positive B cell enhancer mm9_chr9:76084472-76084773 Neighboring gene hypocretin (orexin) receptor 2 Neighboring gene STARR-seq mESC enhancer starr_24681 Neighboring gene STARR-seq mESC enhancer starr_24685 Neighboring gene STARR-seq mESC enhancer starr_24686 Neighboring gene STARR-seq mESC enhancer starr_24687 Neighboring gene STARR-seq mESC enhancer starr_24688 Neighboring gene STARR-seq mESC enhancer starr_24689 Neighboring gene predicted gene, 22938 Neighboring gene predicted gene, 34158

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol 3-kinase catalytic subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol 3-kinase catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol 3-kinase regulatory subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol 3-kinase regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM83B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045518.2 → NP_001038983.1  protein FAM83B

      See identical proteins and their annotated locations for NP_001038983.1

      Status: VALIDATED

      Source sequence(s)
      AC115843, AK049628
      Consensus CDS
      CCDS40695.1
      UniProtKB/Swiss-Prot
      Q0VBM2, Q8BWY1
      Related
      ENSMUSP00000139354.2, ENSMUST00000183437.8
      Conserved Domains (1) summary
      cd09182
      Location:17 → 283
      PLDc_FAM83B_N; N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      76394742..76474397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510953.4 → XP_006511016.1  protein FAM83B isoform X1

      See identical proteins and their annotated locations for XP_006511016.1

      UniProtKB/Swiss-Prot
      Q0VBM2, Q8BWY1
      Conserved Domains (1) summary
      cd09182
      Location:17 → 283
      PLDc_FAM83B_N; N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83B

    2. XM_006510952.4 → XP_006511015.1  protein FAM83B isoform X1

      See identical proteins and their annotated locations for XP_006511015.1

      UniProtKB/Swiss-Prot
      Q0VBM2, Q8BWY1
      Related
      ENSMUSP00000096146.4, ENSMUST00000098546.4
      Conserved Domains (1) summary
      cd09182
      Location:17 → 283
      PLDc_FAM83B_N; N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83B

    3. XM_036154775.1 → XP_036010668.1  protein FAM83B isoform X1

      UniProtKB/Swiss-Prot
      Q0VBM2, Q8BWY1
      Conserved Domains (1) summary
      cd09182
      Location:17 → 283
      PLDc_FAM83B_N; N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83B
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VBM2.1 GenPept UniProtKB/Swiss-Prot:Q0VBM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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