Slc7a13 solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc7a13provided by MGI
Official Full Name: solute carrier family 7, (cationic amino acid transporter, y+ system) member 13provided by MGI
Primary source: MGI:MGI:1921337
See related: Ensembl:ENSMUSG00000041052 AllianceGenome:MGI:1921337
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AGT1; XAT2; AGT-1; 0610009O04Rik
Summary: Enables protein heterodimerization activity. Involved in L-cystine transport; L-glutamate transmembrane transport; and aspartate transmembrane transport. Is active in apical plasma membrane. Is expressed in ileum; liver; male reproductive gland or organ; and metanephros. Orthologous to human SLC7A13 (solute carrier family 7 member 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 4 A3; 4 7.63 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (19818727..19842213)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (19818727..19842213)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a membrane protein AGT1/SLC7A13 is the second partner of rBAT.
Title: Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in L-cystine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: solute carrier family 7 member 13

Names: X-amino acid transporter 2; aspartate/glutamate transporter 1; sodium-independent aspartate/glutamate transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.