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    Sgk2 serum/glucocorticoid regulated kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 27219, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sgk2provided by MGI
    Official Full Name
    serum/glucocorticoid regulated kinase 2provided by MGI
    Primary source
    MGI:MGI:1351318
    See related
    Ensembl:ENSMUSG00000017868 AllianceGenome:MGI:1351318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sgkl
    Summary
    Predicted to enable potassium channel regulator activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in nucleoplasm. Orthologous to human SGK2 (serum/glucocorticoid regulated kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 26.4), liver adult (RPKM 9.0) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Sgk2 in Genome Data Viewer
    Location:
    2 H2; 2 83.93 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (162829249..162856059)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (162987327..163014139)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene L3MBTL1 histone methyl-lysine binding protein Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene intraflagellar transport 52 Neighboring gene STARR-seq mESC enhancer starr_06293 Neighboring gene STARR-seq mESC enhancer starr_06295 Neighboring gene STARR-positive B cell enhancer ABC_E6013 Neighboring gene myeloblastosis oncogene-like 2 Neighboring gene microRNA 7003

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables potassium channel regulator activity  
    enables potassium channel regulator activity  
    enables potassium channel regulator activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in chromatin remodeling  
    involved_in intracellular signal transduction  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    serine/threonine-protein kinase Sgk2
    NP_001278081.1
    NP_001278083.1
    NP_038759.1
    XP_006499721.1
    XP_006499723.1
    XP_011237882.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291152.1NP_001278081.1  serine/threonine-protein kinase Sgk2 isoform b

      See identical proteins and their annotated locations for NP_001278081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. The 5' UTR of this variant is incomplete due to lack of a complete transcript and splice pattern ambiguity in the upstream region.
      Source sequence(s)
      AK050009, AK136559, AV370098, BB350718
      UniProtKB/TrEMBL
      Q3UW73
      Conserved Domains (2) summary
      smart00220
      Location:35291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:39358
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001291154.1NP_001278083.1  serine/threonine-protein kinase Sgk2 isoform c

      See identical proteins and their annotated locations for NP_001278083.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AI747981, AK050009, AL591584, AV370098, BB350718
      Consensus CDS
      CCDS71184.1
      UniProtKB/TrEMBL
      Q3UW73
      Related
      ENSMUSP00000112468.2, ENSMUST00000117123.2
      Conserved Domains (1) summary
      cl21453
      Location:39330
      PKc_like; Protein Kinases, catalytic domain
    3. NM_013731.3NP_038759.1  serine/threonine-protein kinase Sgk2 isoform a

      See identical proteins and their annotated locations for NP_038759.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AI747981, AK050009, AK136559, AV370098, BB350718
      Consensus CDS
      CCDS17004.1
      UniProtKB/Swiss-Prot
      B7ZC31, Q8R0P6, Q9QZS5
      UniProtKB/TrEMBL
      Q3UW73
      Related
      ENSMUSP00000018012.8, ENSMUST00000018012.14
      Conserved Domains (1) summary
      cl21453
      Location:39359
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      162829249..162856059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499660.5XP_006499723.1  serine/threonine-protein kinase Sgk2 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:39283
      PKc_like; Protein Kinases, catalytic domain
    2. XM_011239580.3XP_011237882.1  serine/threonine-protein kinase Sgk2 isoform X2

      See identical proteins and their annotated locations for XP_011237882.1

      UniProtKB/TrEMBL
      Q3UW73
      Conserved Domains (1) summary
      cl21453
      Location:39330
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006499658.5XP_006499721.1  serine/threonine-protein kinase Sgk2 isoform X1

      See identical proteins and their annotated locations for XP_006499721.1

      UniProtKB/Swiss-Prot
      B7ZC31, Q8R0P6, Q9QZS5
      UniProtKB/TrEMBL
      Q3UW73
      Conserved Domains (1) summary
      cl21453
      Location:39359
      PKc_like; Protein Kinases, catalytic domain
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