Thy1 thymus cell antigen 1, theta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Thy1provided by MGI
Official Full Name: thymus cell antigen 1, thetaprovided by MGI
Primary source: MGI:MGI:98747
See related: Ensembl:ENSMUSG00000032011 AllianceGenome:MGI:98747
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: T25; CD90; Thy-1; Thy1.1; Thy1.2; Thy-1.2
Summary: This gene encodes a glycoprotein that is anchored to the cell surface of thymocytes, neuronal and other cells through a glycosyl-phosphatidylinositol moiety. A soluble form of the encoded protein has also been detected in serum and cerebrospinal fluid. The encoded protein undergoes further processing to generate the mature protein which mediates cell-cell interactions to trigger downstream signaling pathways. [provided by RefSeq, Jul 2015]
Expression: Biased expression in thymus adult (RPKM 668.7), cortex adult (RPKM 206.5) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.1; 9 24.52 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (43954681..43959876)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44043384..44048579)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thy-1 restricts steatosis and liver fibrosis in steatotic liver disease.
Title: Thy-1 restricts steatosis and liver fibrosis in steatotic liver disease.
Thy-1 knockdown promotes the osteogenic differentiation of GMSCs via the Wnt/beta-catenin pathway.
Title: Thy-1 knockdown promotes the osteogenic differentiation of GMSCs via the Wnt/β-catenin pathway.
FGF21 alleviates adipose stem cell senescence via CD90 glycosylation-dependent glucose influx in remodeling healthy white adipose tissue.
Title: FGF21 alleviates adipose stem cell senescence via CD90 glycosylation-dependent glucose influx in remodeling healthy white adipose tissue.
Antifibrotic Soluble Thy-1 Correlates with Renal Dysfunction in Chronic Kidney Disease.
Title: Antifibrotic Soluble Thy-1 Correlates with Renal Dysfunction in Chronic Kidney Disease.
Differential Regulation of Innate Lymphoid Cells in Human and Murine Oral Squamous Cell Carcinoma.
Title: Differential Regulation of Innate Lymphoid Cells in Human and Murine Oral Squamous Cell Carcinoma.
Thy-1 plays a pathogenic role and is a potential biomarker for skin fibrosis in scleroderma.
Title: Thy-1 plays a pathogenic role and is a potential biomarker for skin fibrosis in scleroderma.
Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice.
Title: Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice.
These findings identify CD90 as a crucial modulator of S-ADSCs and V-ADSCs to mediate distinct metabolic features of SAT and VAT, thus proposing CD90 as a valuable biomarker or target for evaluating ADSC potentials, monitoring or treating obesity-associated metabolic disorders.
Title: CD90 serves as differential modulator of subcutaneous and visceral adipose-derived stem cells by regulating AKT activation that influences adipose tissue and metabolic homeostasis.
CD90 depletion data demonstrated that local COX-2 overexpression targeted CD90(+) mSSCs to accelerate fracture repair. In conclusion, CD90(+) mSSCs are promising targets for the acceleration of bone repair.
Title: Cyclooxygenase 2 augments osteoblastic but suppresses chondrocytic differentiation of CD90(+) skeletal stem cells in fracture sites.
the impact of Thy-1 expression on mesenchymal stem cell (MSC) fate between osteogenic and adipogenic differentiation and consequences for bone formation and adipose tissue development in vivo, was investigated.
Title: Thy-1 (CD90) promotes bone formation and protects against obesity.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Not Applicable (2) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC151011P1 (e-PCR)
- UniSTS:271131

PMC22863P1 (e-PCR)
- UniSTS:272165

Thy1 (e-PCR), detects polymorphism
- UniSTS:498488

D8Wox34 (e-PCR)
- UniSTS:519012

Thy1 (e-PCR), detects polymorphism
- UniSTS:498327

Thy1 (e-PCR), detects polymorphism
- UniSTS:527577

Thy1 (e-PCR), detects polymorphism
- UniSTS:144620

Thy1 (e-PCR), detects polymorphism
- UniSTS:498412

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GPI anchor binding	ISO Inferred from Sequence Orthology more info
enables GPI anchor binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_positive_effect cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect negative regulation of neuron projection regeneration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cellular extravasation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Rho-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in retinal cone cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axolemma	ISO Inferred from Sequence Orthology more info
located_in axolemma	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: thy-1 membrane glycoprotein

Names: thy-1 antigen

NP_033408.1

EC 3.1.26.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.