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    1700088E04Rik RIKEN cDNA 1700088E04 gene [ Mus musculus (house mouse) ]

    Gene ID: 27660, updated on 9-Dec-2024

    Summary

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    Official Symbol
    1700088E04Rikprovided by MGI
    Official Full Name
    RIKEN cDNA 1700088E04 geneprovided by MGI
    Primary source
    MGI:MGI:1920774
    See related
    Ensembl:ENSMUSG00000033029 AllianceGenome:MGI:1920774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTJ0827E04
    Summary
    Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human C22orf23 (chromosome 22 open reading frame 23). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 50.6), testis adult (RPKM 45.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See 1700088E04Rik in Genome Data Viewer
    Location:
    15 E1; 15 37.7 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79018855..79025451, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79134655..79141251, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 54 Neighboring gene STARR-positive B cell enhancer ABC_E1482 Neighboring gene STARR-seq mESC enhancer starr_39166 Neighboring gene eukaryotic translation initiation factor 3, subunit L Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing -like 1 Neighboring gene STARR-positive B cell enhancer ABC_E7388 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide F Neighboring gene D6 enhancer downstream of Sox10 Neighboring gene MCS1C/MCS2 enhancer region 5' of Sox10 Neighboring gene SRY (sex determining region Y)-box 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative analyses of the Dominant megacolon-SOX10 genomic interval in mouse and human. Southard-Smith EM, et al. Mamm Genome, 1999 Jul. PMID 10384052
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106949

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    UPF0193 protein EVG1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310576.1 → NP_001297505.1  UPF0193 protein EVG1 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) is shorter missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK006539, AK007028, AL589670, BQ175214
      Consensus CDS
      CCDS79387.1
      UniProtKB/TrEMBL
      A0A087WRF9
      Related
      ENSMUSP00000140611.2, ENSMUST00000190509.7
      Conserved Domains (1) summary
      pfam05250
      Location:6 → 190
      UPF0193; uncharacterized protein family (UPF0193)

    2. NM_001310579.1 → NP_001297508.1  UPF0193 protein EVG1 homolog isoform 3

      See identical proteins and their annotated locations for NP_001297508.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. The resulting isoform (3) is shorter missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK006539, AK007028, AL589670, BC144714, BQ175214
      Consensus CDS
      CCDS79388.1
      UniProtKB/TrEMBL
      Q4V9V4
      Related
      ENSMUSP00000139884.2, ENSMUST00000190730.7
      Conserved Domains (1) summary
      pfam05250
      Location:6 → 150
      UPF0193; uncharacterized protein family (UPF0193)

    3. NM_001310581.1 → NP_001297510.1  UPF0193 protein EVG1 homolog isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate donor splice site in the 5' region and lacks an in-frame coding exon compared to variant 1. This results in translation initiation from an in-frame downstream start codon and an isoform (4) with a shorter N-terminus and missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK006539, AK007028, AL589670, AL591921, BC144715, BQ175214
      UniProtKB/TrEMBL
      B7ZMP0
      Conserved Domains (1) summary
      pfam05250
      Location:1 → 115
      UPF0193; uncharacterized protein family (UPF0193)

    4. NM_138581.2 → NP_613047.1  UPF0193 protein EVG1 homolog isoform 1

      See identical proteins and their annotated locations for NP_613047.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA008475, AK006539, AL589670, BB602239
      Consensus CDS
      CCDS27633.1
      UniProtKB/Swiss-Prot
      Q9D9S1
      UniProtKB/TrEMBL
      Q14AC9
      Related
      ENSMUSP00000129244.2, ENSMUST00000169604.8
      Conserved Domains (1) summary
      pfam05250
      Location:6 → 211
      UPF0193; uncharacterized protein family (UPF0193)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79018855..79025451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9S1.1 GenPept UniProtKB/Swiss-Prot:Q9D9S1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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