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    Abhd2 abhydrolase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 54608, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abhd2provided by MGI
    Official Full Name
    abhydrolase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1914344
    See related
    Ensembl:ENSMUSG00000039202 AllianceGenome:MGI:1914344
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LABH2; Labh-2; 2210009N18Rik
    Summary
    Predicted to enable carboxylic ester hydrolase activity; hormone binding activity; and nuclear steroid receptor activity. Involved in acrosome reaction. Acts upstream of or within negative regulation of smooth muscle cell migration and response to wounding. Located in acrosomal vesicle. Is expressed in several structures, including cardiovascular system; central nervous system; endocrine gland; genitourinary system; and sensory organ. Orthologous to human ABHD2 (abhydrolase domain containing 2, acylglycerol lipase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 82.7), adrenal adult (RPKM 56.2) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Abhd2 in Genome Data Viewer
    Location:
    7 44.96 cM; 7 D2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (78923002..79015257)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79273266..79361601)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39040 Neighboring gene STARR-seq mESC enhancer starr_19267 Neighboring gene STARR-positive B cell enhancer ABC_E47 Neighboring gene predicted gene, 31510 Neighboring gene predicted gene, 39041 Neighboring gene predicted gene, 24224 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:86508405-86508675 Neighboring gene STARR-positive B cell enhancer ABC_E9694 Neighboring gene retinaldehyde binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_19276 Neighboring gene predicted gene, 31653 Neighboring gene Fanconi anemia, complementation group I

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Clone Names

    • MGC107122

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylesterase activity  
    enables acetylesterase activity  
    enables acetylesterase activity  
    enables diacylglycerol lipase activity  
    enables diacylglycerol lipase activity  
    enables hormone binding  
    enables hormone binding  
    enables monoacylglycerol lipase activity  
    enables monoacylglycerol lipase activity  
    enables monoacylglycerol lipase activity  
    enables nuclear steroid receptor activity  
    enables nuclear steroid receptor activity  
    enables triacylglycerol lipase activity  
    Process Evidence Code Pubs
    involved_in acrosome reaction PubMed 
    involved_in acylglycerol catabolic process  
    involved_in acylglycerol catabolic process  
    involved_in acylglycerol catabolic process  
    involved_in medium-chain fatty acid biosynthetic process  
    involved_in medium-chain fatty acid catabolic process  
    acts_upstream_of_or_within negative regulation of smooth muscle cell migration PubMed 
    involved_in response to progesterone  
    involved_in response to progesterone  
    acts_upstream_of_or_within response to wounding PubMed 
    acts_upstream_of smooth muscle cell migration PubMed 
    involved_in sperm capacitation  
    involved_in sperm capacitation  
    involved_in sperm capacitation  
    involved_in steroid hormone receptor signaling pathway  
    involved_in steroid hormone receptor signaling pathway  
    involved_in steroid hormone receptor signaling pathway  
    Component Evidence Code Pubs
    located_in acrosomal membrane  
    located_in acrosomal vesicle PubMed 
    is_active_in sperm flagellum  
    located_in sperm flagellum  
    located_in sperm flagellum  
    is_active_in sperm plasma membrane  
    located_in sperm plasma membrane  
    located_in sperm plasma membrane  

    General protein information

    Preferred Names
    monoacylglycerol lipase ABHD2
    Names
    2-arachidonoylglycerol hydrolase
    abhydrolase domain-containing protein 2
    acetylesterase
    alpha/beta hydrolase fold protein
    lung alpha/beta hydrolase 2
    mmLABH2
    triacylglycerol lipase
    NP_061281.3
    XP_036009150.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018811.6NP_061281.3  monoacylglycerol lipase ABHD2

      See identical proteins and their annotated locations for NP_061281.3

      Status: PROVISIONAL

      Source sequence(s)
      AC160464
      Consensus CDS
      CCDS21380.1
      UniProtKB/Swiss-Prot
      Q3U5E8, Q5FWC6, Q9D7Y8, Q9QXM0
      Related
      ENSMUSP00000038361.7, ENSMUST00000037315.13
      Conserved Domains (1) summary
      cl21494
      Location:65400
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      78923002..79015257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153257.1XP_036009150.1  monoacylglycerol lipase ABHD2 isoform X1

      UniProtKB/Swiss-Prot
      Q3U5E8, Q5FWC6, Q9D7Y8, Q9QXM0
      Conserved Domains (1) summary
      cl21494
      Location:65400
      Abhydrolase; alpha/beta hydrolases
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