mt-Nd4 NADH dehydrogenase 4, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: mt-Nd4provided by MGI
Official Full Name: NADH dehydrogenase 4, mitochondrialprovided by MGI
Primary source: MGI:MGI:102498
See related: AllianceGenome:MGI:102498
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus (strain: C57BL/6J)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ND4
Summary: Predicted to enable NADH dehydrogenase (ubiquinone) activity and ubiquinone binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in electron transport coupled proton transport; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Parkinson's disease; macular degeneration; and schizophrenia. Orthologous to human MT-ND4 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	MT (non-nuclear)	NC_005089.1 (10167..11544)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	MT (non-nuclear)	NC_005089.1 (10167..11544)

Chromosome MT - NC_005089.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cybrid mice showed normal respiratory function whether or not their mtDNA possessed the A11181G mutation of the mt-Nd4 gene, suggesting that the this mutation is not responsible for respiration defects found in SAMP8 mice.
Title: Nuclear but not mitochondrial DNA involvement in respiratory complex I defects found in senescence-accelerated mouse strain, SAMP8.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136484 (e-PCR)
- UniSTS:210468

mt-Co3 (e-PCR), detects polymorphism
- UniSTS:143918

mt-Nd3 (e-PCR), detects polymorphism
- UniSTS:143919

RH136233 (e-PCR)
- UniSTS:210227

RH136521 (e-PCR)
- UniSTS:210503

RH136532 (e-PCR)
- UniSTS:210514

RH136545 (e-PCR)
- UniSTS:210527

RH136286 (e-PCR)
- UniSTS:210279

NoName (e-PCR)
- UniSTS:234089

NoName (e-PCR)
- UniSTS:234091

NoName (e-PCR)
- UniSTS:234092

NoName (e-PCR)
- UniSTS:234093

NoName (e-PCR)
- UniSTS:234094

NoName (e-PCR)
- UniSTS:234095

RH136564 (e-PCR)
- UniSTS:210544

RH136324 (e-PCR)
- UniSTS:210315

RH136327 (e-PCR)
- UniSTS:210317

RH136387 (e-PCR)
- UniSTS:210377

RH136397 (e-PCR)
- UniSTS:210387

RH136401 (e-PCR)
- UniSTS:210391

RH136408 (e-PCR)
- UniSTS:210398

RH125467 (e-PCR)
- UniSTS:162286

RH125521 (e-PCR)
- UniSTS:162286

RH125483 (e-PCR)
- UniSTS:162302

Homology

Orthologs from OrthoDB

variation

Loc: 10847 replace = a
Loc: 11181 replace = g

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to NADH dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquinone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IBA Inferred from Biological aspect of Ancestor more info
involved_in aerobic respiration	NAS Non-traceable Author Statement more info	PubMed
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
involved_in electron transport coupled proton transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to nicotine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISO Inferred from Sequence Orthology more info