Grb10 growth factor receptor bound protein 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grb10provided by RGD
Official Full Name: growth factor receptor bound protein 10provided by RGD
Primary source: RGD:1566234
See related: EnsemblRapid:ENSRNOG00000004290 AllianceGenome:RGD:1566234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566234
Summary: Enables insulin receptor binding activity. Involved in insulin receptor signaling pathway; negative regulation of glycogen biosynthetic process; and positive regulation of phosphorylation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Orthologous to human GRB10 (growth factor receptor bound protein 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 551.4), Adrenal (RPKM 499.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (90708653..90816399, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (86495051..86602800, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (92021851..92122249, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In rat uterus, enforced miR199a expression suppresses cell proliferation partially through targeting Grb10.
Title: MiR199a is implicated in embryo implantation by regulating Grb10 in rat.
findings indicate that endogenous overexpression of Grb10 functions as a suppressor of the IGF1-IR pathway, which may represent an important mechanism for regulating cognitive disorder in diabetes
Title: Growth factor receptor-bound protein 10-mediated negative regulation of the insulin-like growth factor-1 receptor-activated signalling pathway results in cognitive disorder in diabetic rats.

Submit: New GeneRIF Correction

General gene information

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Markers

Grb10 (e-PCR), detects polymorphism
- UniSTS:305533

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_negative_effect ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_negative_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of D-glucose import	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glycogen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to insulin	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vascular associated smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: growth factor receptor-bound protein 10

Names: GRB10 adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401403.1 → NP_001388332.1 growth factor receptor-bound protein 10 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P0CE43
NM_001401404.1 → NP_001388333.1 growth factor receptor-bound protein 10 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A0G2JYJ1

Related

ENSRNOP00000070674.1, ENSRNOT00000085175.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

90708653..90816399 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273491.1 → XP_063129561.1 growth factor receptor-bound protein 10 isoform X8
XM_063273489.1 → XP_063129559.1 growth factor receptor-bound protein 10 isoform X6
XM_063273488.1 → XP_063129558.1 growth factor receptor-bound protein 10 isoform X5

UniProtKB/Swiss-Prot

P0CE43
XM_063273487.1 → XP_063129557.1 growth factor receptor-bound protein 10 isoform X5

UniProtKB/Swiss-Prot

P0CE43
XM_063273492.1 → XP_063129562.1 growth factor receptor-bound protein 10 isoform X8
XM_063273486.1 → XP_063129556.1 growth factor receptor-bound protein 10 isoform X4

UniProtKB/TrEMBL

A0A0G2JYJ1
XM_039092313.2 → XP_038948241.1 growth factor receptor-bound protein 10 isoform X3

Related

ENSRNOP00000099840.1, ENSRNOT00000153825.1

Conserved Domains (4) summary

cd10415
Location:529 → 636

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:328 → 450

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:208 → 299

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:468 → 509

BPS; BPS (Between PH and SH2)
XM_063273490.1 → XP_063129560.1 growth factor receptor-bound protein 10 isoform X7
XM_039092307.2 → XP_038948235.1 growth factor receptor-bound protein 10 isoform X1

Related

ENSRNOP00000048487.5, ENSRNOT00000044726.6

Conserved Domains (4) summary

cd10415
Location:584 → 691

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:383 → 505

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:266 → 354

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:523 → 564

BPS; BPS (Between PH and SH2)
XM_039092311.2 → XP_038948239.1 growth factor receptor-bound protein 10 isoform X2

UniProtKB/TrEMBL

A0A9M1XG80

Related

ENSRNOP00000100101.1, ENSRNOT00000165114.1

Conserved Domains (4) summary

cd10415
Location:529 → 636

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:328 → 450

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:211 → 299

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:468 → 509

BPS; BPS (Between PH and SH2)
XM_039092308.2 → XP_038948236.1 growth factor receptor-bound protein 10 isoform X4

UniProtKB/TrEMBL

A0A0G2JYJ1

Conserved Domains (4) summary

cd10415
Location:529 → 636

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:328 → 450

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:211 → 299

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:468 → 509

BPS; BPS (Between PH and SH2)
XM_039092309.2 → XP_038948237.1 growth factor receptor-bound protein 10 isoform X4

UniProtKB/TrEMBL

A0A0G2JYJ1

Conserved Domains (4) summary

cd10415
Location:529 → 636

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:328 → 450

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:211 → 299

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:468 → 509

BPS; BPS (Between PH and SH2)
XM_039092315.2 → XP_038948243.1 growth factor receptor-bound protein 10 isoform X5

UniProtKB/Swiss-Prot

P0CE43

Conserved Domains (4) summary

cd10415
Location:492 → 599

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:291 → 413

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:174 → 262

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:431 → 472

BPS; BPS (Between PH and SH2)
XM_039092316.2 → XP_038948244.1 growth factor receptor-bound protein 10 isoform X5

UniProtKB/Swiss-Prot

P0CE43

Conserved Domains (4) summary

cd10415
Location:492 → 599

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:291 → 413

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:174 → 262

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:431 → 472

BPS; BPS (Between PH and SH2)
XM_039092310.2 → XP_038948238.1 growth factor receptor-bound protein 10 isoform X4

UniProtKB/TrEMBL

A0A0G2JYJ1

Conserved Domains (4) summary

cd10415
Location:529 → 636

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:328 → 450

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:211 → 299

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:468 → 509

BPS; BPS (Between PH and SH2)
XM_039092317.2 → XP_038948245.1 growth factor receptor-bound protein 10 isoform X5

UniProtKB/Swiss-Prot

P0CE43

Conserved Domains (4) summary

cd10415
Location:492 → 599

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:291 → 413

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:174 → 262

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:431 → 472

BPS; BPS (Between PH and SH2)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001109093.1: Suppressed sequence

Description

NM_001109093.1: This RefSeq was removed because currently there is insufficient support for the transcript.