Cdc42 cell division cycle 42 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdc42provided by RGD
Official Full Name: cell division cycle 42provided by RGD
Primary source: RGD:71043
See related: EnsemblRapid:ENSRNOG00000013536 AllianceGenome:RGD:71043
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GTP binding activity and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including actin filament branching; establishment of Golgi localization; and regulation of synapse organization. Located in Golgi membrane; plasma membrane; and secretory granule. Is active in Schaffer collateral - CA1 synapse. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 651.4), Thymus (RPKM 615.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (154838478..154876629, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (149555069..149593239, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (155690267..155728385, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The distinct localization of CDC42 isoforms is responsible for their specific functions during migration.
Title: The distinct localization of CDC42 isoforms is responsible for their specific functions during migration.
Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by Inhibiting Glycogen Synthase Kinase-3beta.
Title: Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by Inhibiting Glycogen Synthase Kinase-3β.
Spatiotemporal distribution of PKCalpha, Cdc42, and Rac1 before directed cell migration.
Title: Spatiotemporal distribution of PKCα, Cdc42, and Rac1 before directed cell migration.
Cdc42 activates paracellular transport in polarised submandibular gland cells.
Title: Cdc42 activates paracellular transport in polarised submandibular gland cells.
Loss of cell polarity regulated by PTEN/Cdc42 enrolled in the process of Hepatopulmonary Syndrome.
Title: Loss of cell polarity regulated by PTEN/Cdc42 enrolled in the process of Hepatopulmonary Syndrome.
CDC42 contributes to vascular calcification in chronic kidney disease through a mechanism involving AKT signaling.
Title: CDC42 promotes vascular calcification in chronic kidney disease.
Study demonstrated that the RhoA-mDia1 and Cdc42 pathways regulate Activin B-induced BMSC migration.
Title: mDia1 and Cdc42 Regulate Activin B-Induced Migration of Bone Marrow-Derived Mesenchymal Stromal Cells.
Cdc42 may played a role in myocardial I/R via JNK , Bcl-2 and Bax signal pathway.
Title: Effect of Cdc42 on myocardial ischemia-reperfusion of rats.
model involving membrane shape changes predicts a localized GTP-Cdc42 pulse results in nucleation of a cortical patch
Title: Membrane shape-mediated wave propagation of cortical protein dynamics.
role of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor
Title: Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137463 (e-PCR)
- UniSTS:219551

CDC42 (e-PCR)
- UniSTS:278181

Cdc42 (e-PCR), detects polymorphism
- UniSTS:256421

UniSTS:224478 (e-PCR)
- UniSTS:224478

Cdc42 (e-PCR), detects polymorphism
- UniSTS:141302

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GBD domain binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	TAS Traceable Author Statement more info	PubMed
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables apolipoprotein A-I receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables thioesterase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament branching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adherens junction organization	ISO Inferred from Sequence Orthology more info
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac conduction system development	ISO Inferred from Sequence Orthology more info
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendritic cell migration	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic heart tube development	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
involved_in endothelin receptor signaling pathway involved in heart process	ISO Inferred from Sequence Orthology more info
involved_in establishment of Golgi localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	TAS Traceable Author Statement more info	PubMed
involved_in establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell apical/basal polarity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment or maintenance of apical/basal cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of cell polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within filopodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart contraction	ISO Inferred from Sequence Orthology more info
involved_in heart process	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in modulation by host of viral process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron fate determination	ISO Inferred from Sequence Orthology more info
involved_in neuropilin signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nuclear migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleus localization	ISO Inferred from Sequence Orthology more info
involved_in organelle transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of catalytic activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell proliferation involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pinocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pinocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of pseudopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synapse structural plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in regulation of attachment of spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of exocytosis	TAS Traceable Author Statement more info	PubMed
involved_in regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic structure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	TAS Traceable Author Statement more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in submandibular salivary gland formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
part_of Golgi transport complex	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
is_active_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
located_in leading edge membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISS Inferred from Sequence or Structural Similarity more info
located_in storage vacuole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell division control protein 42 homolog

Names: cell division cycle 42 (GTP binding protein); cell division cycle 42 homolog

NP_741991.3

EC 3.6.5.2

XP_008762508.1

EC 3.6.5.2

XP_008762509.1

EC 3.6.5.2

XP_038966637.1

EC 3.6.5.2

XP_063144422.1

EC 3.6.5.2

XP_063144423.1

EC 3.6.5.2

XP_063144424.1

EC 3.6.5.2

XP_063144425.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_171994.5 → NP_741991.3 cell division control protein 42 homolog

See identical proteins and their annotated locations for NP_741991.3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q6P9Y3, Q71TW5, Q8CFN2

UniProtKB/TrEMBL

A6ITD3

Related

ENSRNOP00000030928.2, ENSRNOT00000029025.7

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

154838478..154876629 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008764287.4 → XP_008762509.1 cell division control protein 42 homolog isoform X2

See identical proteins and their annotated locations for XP_008762509.1

UniProtKB/TrEMBL

A0A0G2JSM8, A6ITD4

Related

ENSRNOP00000018118.2, ENSRNOT00000018118.7

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
XM_063288354.1 → XP_063144424.1 cell division control protein 42 homolog isoform X1

UniProtKB/Swiss-Prot

Q6P9Y3, Q71TW5, Q8CFN2

UniProtKB/TrEMBL

A6ITD3
XM_063288355.1 → XP_063144425.1 cell division control protein 42 homolog isoform X2

UniProtKB/TrEMBL

A0A0G2JSM8, A6ITD4
XM_063288352.1 → XP_063144422.1 cell division control protein 42 homolog isoform X2

UniProtKB/TrEMBL

A0A0G2JSM8, A6ITD4
XM_008764286.4 → XP_008762508.1 cell division control protein 42 homolog isoform X1

See identical proteins and their annotated locations for XP_008762508.1

UniProtKB/Swiss-Prot

Q6P9Y3, Q71TW5, Q8CFN2

UniProtKB/TrEMBL

A6ITD3

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
XM_039110709.2 → XP_038966637.1 cell division control protein 42 homolog isoform X1

UniProtKB/Swiss-Prot

Q6P9Y3, Q71TW5, Q8CFN2

UniProtKB/TrEMBL

A6ITD3

Conserved Domains (1) summary

cd01874
Location:3 → 177

Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
XM_063288353.1 → XP_063144423.1 cell division control protein 42 homolog isoform X2

UniProtKB/TrEMBL

A0A0G2JSM8, A6ITD4