Slc25a5 solute carrier family 25 member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a5provided by RGD
Official Full Name: solute carrier family 25 member 5provided by RGD
Primary source: RGD:620353
See related: EnsemblRapid:ENSRNOG00000039980 AllianceGenome:RGD:620353
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ant2
Summary: Predicted to enable several functions, including ATP:ADP antiporter activity; oxidative phosphorylation uncoupler activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including hemopoiesis; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and nucleotide transmembrane transport. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in membrane raft and mitochondrial inner membrane. Orthologous to human SLC25A5 (solute carrier family 25 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 4946.0), Thymus (RPKM 2146.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (120897616..120900683)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (116031896..116034963)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (123404570..123407637)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

knockdown of the major ANT isoforms, ANT2 and ANT3, did not collapse DeltaPsi after respiratory inhibition. These findings indicated that ANT did mediate mitochondrial ATP/ADP exchange in cancer cells.
Title: ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells Is Independent of the Adenine Nucleotide Translocator.
These findings demonstrate the gonadotropin stimulation of Btg2 in the ovary and, the physical interaction of Btg2 with Ant2 in mitochondria.
Title: B-cell translocation gene 2: expression in the rat ovary and potential association with adenine nucleotide translocase 2 in mitochondria.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc25a5 (e-PCR), detects polymorphism
- UniSTS:545996

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP:ADP antiporter activity	ISO Inferred from Sequence Orthology more info
enables ATP:ADP antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables adenine nucleotide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oxidative phosphorylation uncoupler activity	ISO Inferred from Sequence Orthology more info
enables oxidative phosphorylation uncoupler activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in adaptive thermogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenine nucleotide transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial ADP transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ADP transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial ATP transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ATP transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane permeability	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of MMXD complex	ISO Inferred from Sequence Orthology more info
part_of MMXD complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
part_of mitochondrial permeability transition pore complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial permeability transition pore complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP/ATP translocase 2

Names: ADP,ATP carrier protein 2; ANT 2; adenine nucleotide translocator), member 5; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.