Zbtb7a zinc finger and BTB domain containing 7a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zbtb7aprovided by RGD
Official Full Name: zinc finger and BTB domain containing 7aprovided by RGD
Primary source: RGD:620946
See related: EnsemblRapid:ENSRNOG00000020161 AllianceGenome:RGD:620946
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lrf; OCZF; Zbtb7
Summary: Enables DNA-binding transcription factor activity. Involved in regulation of DNA-templated transcription and regulation of osteoclast differentiation. Predicted to be located in cytoplasm and site of double-strand break. Predicted to be part of DNA-dependent protein kinase complex. Predicted to be active in nucleus. Orthologous to human ZBTB7A (zinc finger and BTB domain containing 7A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 75.7), Spleen (RPKM 68.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (9211733..9229273, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8561015..8578243, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11429266..11446119, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68.
Title: Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68.
The purpose of this study was to obtain clues on how Pokemon is involved in the unfolded protein response.
Title: Low-dose radiation suppresses Pokemon expression under hypoxic conditions.
LRF is the first transcription factor found to bind directly to the COMP gene promoter, to recruit HDAC1, and to regulate both COMP gene expression and chondrogenic differentiation
Title: Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase binding	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear androgen receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via classical nonhomologous end joining	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via classical nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via classical nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
involved_in erythrocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of androgen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of androgen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of DNA-dependent protein kinase complex	IEA Inferred from Electronic Annotation more info
part_of DNA-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 7A

Names: leukemia/lymphoma-related factor; osteoclast-derived zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054002.2 → NP_446454.2 zinc finger and BTB domain-containing protein 7A

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q9QZ48

UniProtKB/TrEMBL

A6K8C0, G3V8P6

Related

ENSRNOP00000027323.3, ENSRNOT00000027323.7

Conserved Domains (3) summary

sd00017
Location:406 → 426

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18326
Location:9 → 128

BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)

pfam13465
Location:419 → 443

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

9211733..9229273 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240838.5 → XP_006240900.1 zinc finger and BTB domain-containing protein 7A isoform X2

See identical proteins and their annotated locations for XP_006240900.1

UniProtKB/Swiss-Prot

Q9QZ48

UniProtKB/TrEMBL

A6K8C0, G3V8P6

Conserved Domains (3) summary

sd00017
Location:406 → 426

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18326
Location:9 → 128

BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)

pfam13465
Location:419 → 443

zf-H2C2_2; Zinc-finger double domain
XM_006240837.5 → XP_006240899.1 zinc finger and BTB domain-containing protein 7A isoform X2

See identical proteins and their annotated locations for XP_006240899.1

UniProtKB/Swiss-Prot

Q9QZ48

UniProtKB/TrEMBL

A6K8C0, G3V8P6

Conserved Domains (3) summary

sd00017
Location:406 → 426

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18326
Location:9 → 128

BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)

pfam13465
Location:419 → 443

zf-H2C2_2; Zinc-finger double domain
XM_063262898.1 → XP_063118968.1 zinc finger and BTB domain-containing protein 7A isoform X2

UniProtKB/Swiss-Prot

Q9QZ48

UniProtKB/TrEMBL

A6K8C0, G3V8P6
XM_006240836.5 → XP_006240898.1 zinc finger and BTB domain-containing protein 7A isoform X1

UniProtKB/Swiss-Prot

Q9QZ48

UniProtKB/TrEMBL

A0A0G2K6Z3

Related

ENSRNOP00000073998.2, ENSRNOT00000082126.3

Conserved Domains (5) summary

smart00225
Location:114 → 210

BTB; Broad-Complex, Tramtrack and Bric a brac

COG5048
Location:455 → 518

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:485 → 505

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:103 → 206

BTB; BTB/POZ domain

pfam13465
Location:498 → 522

zf-H2C2_2; Zinc-finger double domain