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    Bdh1 3-hydroxybutyrate dehydrogenase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117099, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bdh1provided by RGD
    Official Full Name
    3-hydroxybutyrate dehydrogenase 1provided by RGD
    Primary source
    RGD:620131
    See related
    EnsemblRapid:ENSRNOG00000001736 AllianceGenome:RGD:620131
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bdh
    Summary
    Enables 3-hydroxybutyrate dehydrogenase activity and phospholipid binding activity. Involved in several processes, including response to corticosterone; response to estradiol; and response to growth hormone. Located in mitochondrial inner membrane. Biomarker of hyperthyroidism. Orthologous to human BDH1 (3-hydroxybutyrate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 732.0), Heart (RPKM 140.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bdh1 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (82806125..82848133, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (69302534..69343173, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (72577547..72619435, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550974 Neighboring gene uncharacterized LOC120095674 Neighboring gene uncharacterized LOC134481095 Neighboring gene uncharacterized LOC134481093 Neighboring gene uncharacterized LOC134481094 Neighboring gene apolipoprotein D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Comparison of 3-hydroxybutyrate dehydrogenase from bovine heart and rat liver mitochondria. McIntyre JO, et al. Arch Biochem Biophys, 1988 Apr. PMID 3355176
    2. Reactivation of D-beta-hydroxybutyrate dehydrogenase with short-chain lecithins: stoichiometry and kinetic mechanism. Cortese JD, et al. Biochemistry, 1982 Aug 3. PMID 7138813
    3. Effects of digitonin on the intracellular content of rat hepatocytes: implications for its use in the study of intralobular heterogeneity. Racine L, et al. J Histochem Cytochem, 1993 Jul. PMID 8515054
    4. Effect of diabetes, adrenalectomy and hypophysectomy on D-3-hydroxybutyrate dehydrogenase activity and substrate oxidation by rat mitochondria. Bedetti CD, et al. Biochem Int, 1987 Jan. PMID 3551959
    5. Favourable, significant effect of the dose-dependent treatment with RU 38486 (RU) on the alterations of the hepatic mitochondrial function of diabetic rats. Brignone JA, et al. Diabetes Res Clin Pract, 1996 May. PMID 8858202

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94818

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-hydroxybutyrate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxybutyrate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-hydroxybutyrate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3-hydroxybutyrate dehydrogenase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adipose tissue development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to corticosterone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to growth hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to insulin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in matrix side of mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    D-beta-hydroxybutyrate dehydrogenase, mitochondrial
    Names
    3-hydroxybutyrate dehydrogenase (heart, mitochondrial)
    3-hydroxybutyrate dehydrogenase, type 1
    NP_446447.2
    XP_006248540.1
    XP_038943838.1
    XP_038943839.1
    XP_063126315.1
    XP_063126316.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053995.3 → NP_446447.2  D-beta-hydroxybutyrate dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_446447.2

      Status: PROVISIONAL

      Source sequence(s)
      BC085916
      UniProtKB/Swiss-Prot
      P29147, Q5U2Q2
      UniProtKB/TrEMBL
      A0A0G2JSH2, A6IRW3
      Related
      ENSRNOP00000002366.3, ENSRNOT00000002366.7
      Conserved Domains (1) summary
      cd09805
      Location:57 → 342
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      82806125..82848133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248478.5 → XP_006248540.1  D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006248540.1

      UniProtKB/Swiss-Prot
      P29147, Q5U2Q2
      UniProtKB/TrEMBL
      A0A0G2JSH2, A6IRW3
      Conserved Domains (1) summary
      cd09805
      Location:57 → 342
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

    2. XM_063270245.1 → XP_063126315.1  D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P29147, Q5U2Q2
      UniProtKB/TrEMBL
      A0A0G2JSH2, A6IRW3

    3. XM_063270246.1 → XP_063126316.1  D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P29147, Q5U2Q2
      UniProtKB/TrEMBL
      A0A0G2JSH2, A6IRW3

    4. XM_039087910.2 → XP_038943838.1  D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P29147, Q5U2Q2
      UniProtKB/TrEMBL
      A0A0G2JSH2, A6IRW3
      Conserved Domains (1) summary
      cd09805
      Location:57 → 342
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

    5. XM_039087911.2 → XP_038943839.1  D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P29147, Q5U2Q2
      UniProtKB/TrEMBL
      A0A0G2JSH2, A6IRW3
      Conserved Domains (1) summary
      cd09805
      Location:57 → 342
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29147.2 GenPept UniProtKB/Swiss-Prot:P29147

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