Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2e1provided by RGD
Official Full Name: cytochrome P450, family 2, subfamily e, polypeptide 1provided by RGD
Primary source: RGD:2475
See related: EnsemblRapid:ENSRNOG00000012458 AllianceGenome:RGD:2475
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp2e
Summary: Enables Hsp70 protein binding activity and Hsp90 protein binding activity. Involved in several processes, including response to 3-methylcholanthrene; response to ethanol; and response to ozone. Located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Used to study alcohol dependence and drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; liver disease (multiple); middle cerebral artery infarction; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acoustic neuroma; gastrointestinal system cancer (multiple); high grade glioma; liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 11351.2) and Kidney (RPKM 1709.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205269967..205280365)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (195840330..195850728)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (213511892..213522195)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adverse outcome pathway exploration of furan-induced liver fibrosis in rats: Genotoxicity pathway or oxidative stress pathway through CYP2E1 activation?
Title: Adverse outcome pathway exploration of furan-induced liver fibrosis in rats: Genotoxicity pathway or oxidative stress pathway through CYP2E1 activation?
CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma.
Title: CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma.
Cyp2e1 knockdown attenuates high glucose-induced apoptosis and oxidative stress of cardiomyocytes by activating PI3K/Akt signaling.
Title: Cyp2e1 knockdown attenuates high glucose-induced apoptosis and oxidative stress of cardiomyocytes by activating PI3K/Akt signaling.
Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure.
Title: Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure.
Cytochrome P450 2E1 predicts liver functional recovery from donation after circulatory death using air-ventilated normothermic machine perfusion.
Title: Cytochrome P450 2E1 predicts liver functional recovery from donation after circulatory death using air-ventilated normothermic machine perfusion.
Synbiotics Alleviate Hepatic Damage, Intestinal Injury and Muscular Beclin-1 Elevation in Rats after Chronic Ethanol Administration.
Title: Synbiotics Alleviate Hepatic Damage, Intestinal Injury and Muscular Beclin-1 Elevation in Rats after Chronic Ethanol Administration.
Alcohol suppresses cardiovascular diurnal variations in male normotensive rats: Role of reduced PER2 expression and CYP2E1 hyperactivity in the heart.
Title: Alcohol suppresses cardiovascular diurnal variations in male normotensive rats: Role of reduced PER2 expression and CYP2E1 hyperactivity in the heart.
Validation of an HPLC Method for the Simultaneous Quantification of Metabolic Reaction Products Catalysed by CYP2E1 Enzyme Activity: Inhibitory Effect of Cytochrome P450 Enzyme CYP2E1 by Salicylic Acid in Rat Liver Microsomes.
Title: Validation of an HPLC Method for the Simultaneous Quantification of Metabolic Reaction Products Catalysed by CYP2E1 Enzyme Activity: Inhibitory Effect of Cytochrome P450 Enzyme CYP2E1 by Salicylic Acid in Rat Liver Microsomes.
The differential changes in CYP2E1 in the processes of alcohol-induced and immune-mediated liver injury may result from the differential expression of inflammatory cytokines and iNOS after NF-kappaB activation, leading to the NF-kappaB-mediated transcriptional regulation of rat CYP2E1 by two independent signaling pathways.
Title: NF-κB-mediated regulation of rat CYP2E1 by two independent signaling pathways.
Overall, high CYP2E1 activity aggravates hepatofibrosis by restraining M2 macrophage polarization, providing a novel insight for understanding the profibrotic activity of CYP2E1 and a promising avenue for hepatofibrosis therapy.
Title: High CYP2E1 activity aggravates hepatofibrosis by limiting macrophage polarization towards the M2 phenotype.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 4-nitrophenol 2-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables 4-nitrophenol 2-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables Hsp70 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables arachidonate epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid omega-1 hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid omega-1 hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	TAS Traceable Author Statement more info	PubMed
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in 4-nitrophenol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in 4-nitrophenol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid hydroxylation	IEA Inferred from Electronic Annotation more info
involved_in lipid hydroxylation	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in monoterpenoid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in monoterpenoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to 3-methylcholanthrene	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ozone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 2E1

Names: 4-nitrophenol 2-hydroxylase; CYPIIE1; P450-J; P450RLM6; cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450-J; cytochrome P450RLM6

NP_113731.2

EC 1.14.13.n7

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031543.2 → NP_113731.2 cytochrome P450 2E1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P05182

UniProtKB/TrEMBL

A0A8L2Q8J4, A6HXJ0

Related

ENSRNOP00000016883.5, ENSRNOT00000016883.8

Conserved Domains (1) summary

cd20665
Location:64 → 487

CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s