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    Mapk4 mitogen-activated protein kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mapk4provided by RGD
    Official Full Name
    mitogen-activated protein kinase 4provided by RGD
    Primary source
    RGD:3047
    See related
    EnsemblRapid:ENSRNOG00000015401 AllianceGenome:RGD:3047
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein dimerization activity; protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK4 (mitogen-activated protein kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 101.7), Brain (RPKM 100.5) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mapk4 in Genome Data Viewer
    Location:
    18q12.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (69788058..69937524, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (67512805..67661271, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (69894692..70043634, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483051 Neighboring gene maestro Neighboring gene uncharacterized LOC120098291 Neighboring gene uncharacterized LOC102551934 Neighboring gene uncharacterized LOC108348860 Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation of a cDNA encoding the rat MAP-kinase homolog of human p63mapk. García JI, et al. Mamm Genome, 1996 Nov. PMID 8875888
    2. Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance. Xu H, et al. J Biol Chem, 2003 Aug 8. PMID 12777378
    3. Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. Kant S, et al. J Biol Chem, 2006 Nov 17. PMID 16973613
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 4
    Names
    ERK-4
    MAP kinase 4
    MAPK 4
    MNK2
    extracellular signal-regulated kinase 4
    p63-MAPK
    NP_062192.1
    XP_008770388.1
    XP_008770389.1
    XP_017456503.1
    XP_038952979.1
    XP_063133592.1
    XP_063133593.1
    XP_063133594.1
    XP_063133595.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019319.1 → NP_062192.1  mitogen-activated protein kinase 4

      See identical proteins and their annotated locations for NP_062192.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6KRD4, G3V9J9
      Related
      ENSRNOP00000050164.3, ENSRNOT00000047271.7
      Conserved Domains (2) summary
      cd07854
      Location:14 → 351
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
      pfam00069
      Location:20 → 312
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      69788058..69937524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772167.4 → XP_008770389.1  mitogen-activated protein kinase 4 isoform X1

      See identical proteins and their annotated locations for XP_008770389.1

      UniProtKB/TrEMBL
      A6KRD4, G3V9J9
      Conserved Domains (2) summary
      cd07854
      Location:14 → 351
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
      pfam00069
      Location:20 → 312
      Pkinase; Protein kinase domain

    2. XM_008772166.4 → XP_008770388.1  mitogen-activated protein kinase 4 isoform X1

      See identical proteins and their annotated locations for XP_008770388.1

      UniProtKB/TrEMBL
      A6KRD4, G3V9J9
      Conserved Domains (2) summary
      cd07854
      Location:14 → 351
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
      pfam00069
      Location:20 → 312
      Pkinase; Protein kinase domain

    3. XM_039097051.2 → XP_038952979.1  mitogen-activated protein kinase 4 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1 → 140
      PKc_like; Protein Kinases, catalytic domain

    4. XM_063277522.1 → XP_063133592.1  mitogen-activated protein kinase 4 isoform X1

      UniProtKB/TrEMBL
      A6KRD4, G3V9J9

    5. XM_017601014.3 → XP_017456503.1  mitogen-activated protein kinase 4 isoform X1

      UniProtKB/TrEMBL
      A6KRD4, G3V9J9
      Conserved Domains (2) summary
      cd07854
      Location:14 → 351
      STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
      pfam00069
      Location:20 → 312
      Pkinase; Protein kinase domain

    6. XM_063277523.1 → XP_063133593.1  mitogen-activated protein kinase 4 isoform X2

    7. XM_063277525.1 → XP_063133595.1  mitogen-activated protein kinase 4 isoform X3

      UniProtKB/Swiss-Prot
      Q63454

    8. XM_063277524.1 → XP_063133594.1  mitogen-activated protein kinase 4 isoform X3

      UniProtKB/Swiss-Prot
      Q63454
      Related
      ENSRNOP00000083194.1, ENSRNOT00000098156.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63454.1 GenPept UniProtKB/Swiss-Prot:Q63454

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