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    CDK12 cyclin dependent kinase 12 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 696733, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CDK12provided by VGNC
    Official Full Name
    cyclin dependent kinase 12provided by VGNC
    Primary source
    VGNC:VGNC:71083
    See related
    Ensembl:ENSMMUG00000021350
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    CRKRS
    Orthologs
    human mouse all
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    Genomic context

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    See CDK12 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (50582046..50693302)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (45247454..45358876)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 20 Neighboring gene cytochrome c oxidase subunit 7C, mitochondrial pseudogene Neighboring gene mediator complex subunit 1 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene neuronal differentiation 2 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cyclin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin/CDK positive transcription elongation factor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-dependent kinase 12
    Names
    Cdc2-related kinase, arginine/serine-rich
    NP_001248675.1
    XP_014975000.1
    XP_028691311.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261746.2 → NP_001248675.1  cyclin-dependent kinase 12

      See identical proteins and their annotated locations for NP_001248675.1

      Status: PROVISIONAL

      Source sequence(s)
      JV047357
      UniProtKB/TrEMBL
      H9F064, I0FSK2
      Related
      ENSMMUP00000066906.1, ENSMMUT00000094133.1
      Conserved Domains (1) summary
      cd07864
      Location:719 → 1020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      50582046..50693302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015119514.2 → XP_014975000.1  cyclin-dependent kinase 12 isoform X1

      UniProtKB/TrEMBL
      H9F064, I0FSK1
      Conserved Domains (2) summary
      smart00220
      Location:727 → 1020
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:719 → 1020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    2. XM_028835478.1 → XP_028691311.1  cyclin-dependent kinase 12 isoform X2

      UniProtKB/TrEMBL
      H9F064, I0FSK2
      Conserved Domains (1) summary
      cd07864
      Location:719 → 1020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    RNA

    1. XR_003723495.1 RNA Sequence

    2. XR_003723494.1 RNA Sequence

    3. XR_003723497.1 RNA Sequence

    4. XR_003723498.1 RNA Sequence

    5. XR_003723500.1 RNA Sequence

    6. XR_003723496.1 RNA Sequence

    7. XR_003723499.1 RNA Sequence

    8. XR_003723503.1 RNA Sequence

    9. XR_003723501.1 RNA Sequence

    10. XR_003723502.1 RNA Sequence

    11. XR_003723504.1 RNA Sequence

    12. XR_003723506.1 RNA Sequence

    13. XR_003723505.1 RNA Sequence

    14. XR_003723507.1 RNA Sequence

    15. XR_003723508.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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