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    WRN WRN RecQ like helicase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 695678, updated on 17-Aug-2024

    Summary

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    Official Symbol
    WRNprovided by VGNC
    Official Full Name
    WRN RecQ like helicaseprovided by VGNC
    Primary source
    VGNC:VGNC:78803
    See related
    Ensembl:ENSMMUG00000022655
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See WRN in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (31339605..31478446)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (31110117..31248761)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA:lysophosphatidylglycerol acyltransferase 1 pseudogene Neighboring gene purine rich element binding protein G Neighboring gene BTB/POZ domain-containing protein KCTD9 pseudogene Neighboring gene uncharacterized LOC106999736

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA unwinding involved in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in G-quadruplex DNA unwinding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Werner syndrome ATP-dependent helicase
    Names
    Werner syndrome RecQ like helicase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      31339605..31478446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028852549.1 → XP_028708382.1  Werner syndrome ATP-dependent helicase isoform X5

      UniProtKB/TrEMBL
      G7MZ24
      Conserved Domains (4) summary
      smart00341
      Location:1151 → 1229
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:537 → 1010
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      PTZ00341
      Location:335 → 480
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd06129
      Location:61 → 229
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins

    2. XM_028852547.1 → XP_028708380.1  Werner syndrome ATP-dependent helicase isoform X2

      UniProtKB/TrEMBL
      G7MZ24
      Conserved Domains (5) summary
      smart00341
      Location:1128 → 1206
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:537 → 987
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      PTZ00341
      Location:335 → 480
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd06129
      Location:61 → 229
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:1235 → 1329
      HTH_40; Helix-turn-helix domain

    3. XM_028852548.1 → XP_028708381.1  Werner syndrome ATP-dependent helicase isoform X3

      UniProtKB/TrEMBL
      G7MZ24
      Conserved Domains (5) summary
      smart00341
      Location:1151 → 1229
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:537 → 1010
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      PTZ00341
      Location:335 → 480
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd06129
      Location:61 → 229
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:1258 → 1352
      HTH_40; Helix-turn-helix domain

    4. XM_028852542.1 → XP_028708375.1  Werner syndrome ATP-dependent helicase isoform X1

      UniProtKB/TrEMBL
      F7FM29, G7MZ24
      Conserved Domains (5) summary
      smart00341
      Location:1151 → 1229
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:537 → 1010
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      PTZ00341
      Location:335 → 480
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd06129
      Location:61 → 229
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:1258 → 1352
      HTH_40; Helix-turn-helix domain

    5. XM_028852545.1 → XP_028708378.1  Werner syndrome ATP-dependent helicase isoform X1

      UniProtKB/TrEMBL
      F7FM29, G7MZ24
      Conserved Domains (5) summary
      smart00341
      Location:1151 → 1229
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:537 → 1010
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      PTZ00341
      Location:335 → 480
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd06129
      Location:61 → 229
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:1258 → 1352
      HTH_40; Helix-turn-helix domain

    6. XM_015145130.2 → XP_015000616.2  Werner syndrome ATP-dependent helicase isoform X1

      UniProtKB/TrEMBL
      F7FM29, G7MZ24
      Conserved Domains (5) summary
      smart00341
      Location:1151 → 1229
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:537 → 1010
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      PTZ00341
      Location:335 → 480
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd06129
      Location:61 → 229
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:1258 → 1352
      HTH_40; Helix-turn-helix domain

    7. XM_015145133.2 → XP_015000619.2  Werner syndrome ATP-dependent helicase isoform X4

      UniProtKB/TrEMBL
      G7MZ24
      Conserved Domains (4) summary
      smart00341
      Location:1124 → 1202
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:510 → 983
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      cd06129
      Location:61 → 229
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:1231 → 1325
      HTH_40; Helix-turn-helix domain

    8. XM_028852543.1 → XP_028708376.1  Werner syndrome ATP-dependent helicase isoform X1

      UniProtKB/TrEMBL
      F7FM29, G7MZ24
      Conserved Domains (5) summary
      smart00341
      Location:1151 → 1229
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:537 → 1010
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      PTZ00341
      Location:335 → 480
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd06129
      Location:61 → 229
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:1258 → 1352
      HTH_40; Helix-turn-helix domain

    9. XM_028852544.1 → XP_028708377.1  Werner syndrome ATP-dependent helicase isoform X1

      UniProtKB/TrEMBL
      F7FM29, G7MZ24
      Related
      ENSMMUP00000029828.4, ENSMMUT00000031879.4
      Conserved Domains (5) summary
      smart00341
      Location:1151 → 1229
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:537 → 1010
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      PTZ00341
      Location:335 → 480
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd06129
      Location:61 → 229
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:1258 → 1352
      HTH_40; Helix-turn-helix domain

    10. XM_028852546.1 → XP_028708379.1  Werner syndrome ATP-dependent helicase isoform X1

      UniProtKB/TrEMBL
      F7FM29, G7MZ24
      Conserved Domains (5) summary
      smart00341
      Location:1151 → 1229
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:537 → 1010
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      PTZ00341
      Location:335 → 480
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd06129
      Location:61 → 229
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:1258 → 1352
      HTH_40; Helix-turn-helix domain

    11. XM_028852541.1 → XP_028708374.1  Werner syndrome ATP-dependent helicase isoform X1

      UniProtKB/TrEMBL
      F7FM29, G7MZ24
      Conserved Domains (5) summary
      smart00341
      Location:1151 → 1229
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:537 → 1010
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      PTZ00341
      Location:335 → 480
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      cd06129
      Location:61 → 229
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:1258 → 1352
      HTH_40; Helix-turn-helix domain

    RNA

    1. XR_003732319.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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