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    TLE1 TLE family member 1, transcriptional corepressor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707336, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TLE1provided by VGNC
    Official Full Name
    TLE family member 1, transcriptional corepressorprovided by VGNC
    Primary source
    VGNC:VGNC:78364
    See related
    Ensembl:ENSMMUG00000003718
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human all
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    Genomic context

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    See TLE1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (96928548..97036586, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (97944881..98053489, complement)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106993821 Neighboring gene CST complex subunit TEN1-like Neighboring gene uncharacterized LOC106993810 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORD95

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transducin-like enhancer protein 1
    Names
    transducin like enhancer of split 1
    transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001265628.1 → NP_001252557.1  transducin-like enhancer protein 1

      See identical proteins and their annotated locations for NP_001252557.1

      Status: PROVISIONAL

      Source sequence(s)
      JV667465
      UniProtKB/TrEMBL
      A0A5K1VAB6, G7NGE0
      Related
      ENSMMUP00000004961.4, ENSMMUT00000005266.4
      Conserved Domains (4) summary
      PHA03247
      Location:319 → 476
      PHA03247; large tegument protein UL36; Provisional
      cd00200
      Location:483 → 767
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:487 → 526
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      96928548..97036586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015117967.2 → XP_014973453.1  transducin-like enhancer protein 1 isoform X4

      UniProtKB/TrEMBL
      G7NGE0
      Conserved Domains (4) summary
      PHA03247
      Location:329 → 486
      PHA03247; large tegument protein UL36; Provisional
      cd00200
      Location:493 → 777
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:497 → 536
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    2. XM_015117970.2 → XP_014973456.1  transducin-like enhancer protein 1 isoform X8

      UniProtKB/TrEMBL
      G7NGE0
      Conserved Domains (3) summary
      cd00200
      Location:482 → 766
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:486 → 525
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    3. XM_015117963.2 → XP_014973449.1  transducin-like enhancer protein 1 isoform X1

      UniProtKB/TrEMBL
      G7NGE0
      Conserved Domains (4) summary
      COG2319
      Location:520 → 812
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:527 → 811
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:531 → 570
      7WD40; WD40 repeat [structural motif]

    4. XM_015117968.2 → XP_014973454.1  transducin-like enhancer protein 1 isoform X5

      UniProtKB/TrEMBL
      G7NGE0
      Conserved Domains (3) summary
      cd00200
      Location:492 → 776
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:496 → 535
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    5. XM_015117969.2 → XP_014973455.1  transducin-like enhancer protein 1 isoform X6

      UniProtKB/TrEMBL
      F6S807, I2CYU3
      Conserved Domains (4) summary
      COG2319
      Location:464 → 756
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:471 → 755
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 77
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:475 → 514
      7WD40; WD40 repeat [structural motif]

    6. XM_015117966.2 → XP_014973452.1  transducin-like enhancer protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A1D5Q377, G7NGE0
      Related
      ENSMMUP00000042489.1, ENSMMUT00000077751.2
      Conserved Domains (4) summary
      COG2319
      Location:510 → 802
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:517 → 801
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:521 → 560
      7WD40; WD40 repeat [structural motif]

    7. XM_015117965.2 → XP_014973451.1  transducin-like enhancer protein 1 isoform X2

      UniProtKB/TrEMBL
      G7NGE0
      Conserved Domains (4) summary
      COG2319
      Location:519 → 811
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:526 → 810
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:530 → 569
      7WD40; WD40 repeat [structural motif]

    8. XM_028834304.1 → XP_028690137.1  transducin-like enhancer protein 1 isoform X7

      UniProtKB/TrEMBL
      F6S807, I2CYU3
      Conserved Domains (2) summary
      cd00200
      Location:412 → 696
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:416 → 455
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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